Chromones

Cytotoxic Activity of C -Geranyl Compounds from Paulownia tomentosa Fruits

Medicinal Chemistry / Complementary and Alternative Medicine / Plant Biology / Tobacco / Medicinal Plants / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta

Cytotoxic Activity of C -Geranyl Compounds from Paulownia tomentosa Fruits

Medicinal Chemistry / Complementary and Alternative Medicine / Plant Biology / Tobacco / Medicinal Plants / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta

Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM

Radiobiology of Ionizing Radiation / DNA damage / DNA repair / Dogs / Animals / Phosphorylation / Histones / Chromones / Biochemistry and cell biology / Phosphorylation / Histones / Chromones / Biochemistry and cell biology

Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells

RNA / Enzyme Inhibitors / Gene expression / Western blotting / Humans / Endothelial Cells / Cholesterol / Nitric oxide / NF-kappa B / mRna expression levels / Time Dependent / Endothelial cell / Protein Expression / Protein Phosphorylation / Chromones / Cell Survival / Endothelial Cells / Cholesterol / Nitric oxide / NF-kappa B / mRna expression levels / Time Dependent / Endothelial cell / Protein Expression / Protein Phosphorylation / Chromones / Cell Survival

Enhancement of a pentacyclic tyrosine kinase inhibitor production in Cladosporium cf. cladosporioides by Cladosporol

Enzyme Inhibitors / Multidisciplinary / Applied Microbiology and Biotechnology / Tyrosine Kinase Inhibitor / Biotransformation / Chromones / Molecular Structure / Cladosporium / Chromones / Molecular Structure / Cladosporium

Enhancement of a pentacyclic tyrosine kinase inhibitor production in Cladosporium cf. cladosporioides by Cladosporol

Enzyme Inhibitors / Multidisciplinary / Applied Microbiology and Biotechnology / Tyrosine Kinase Inhibitor / Biotransformation / Chromones / Molecular Structure / Cladosporium / Chromones / Molecular Structure / Cladosporium

Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

Cancer / Flow Cytometry / Cell Cycle / DNA damage / Cell line / Humans / Mice / Female / Animals / Phosphorylation / Histones / Colon cancer / Protein Kinase / Ionizing Radiation / Cell Cycle Arrest / Chromones / Tumor Growth / Therapeutic Use / Protein Kinase Inhibitors / Humans / Mice / Female / Animals / Phosphorylation / Histones / Colon cancer / Protein Kinase / Ionizing Radiation / Cell Cycle Arrest / Chromones / Tumor Growth / Therapeutic Use / Protein Kinase Inhibitors

The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells

Proteomics / Enzyme Inhibitors / Apoptosis / Molecular chaperones / Humans / Tandem Mass Spectrometry / Glycolysis / Chromones / Biochemistry and cell biology / Adenosine Triphosphate / Tandem Mass Spectrometry / Glycolysis / Chromones / Biochemistry and cell biology / Adenosine Triphosphate

Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 Cells

Drug interactions / Flavonoids / Mice / Animals / Naphthoquinones / Superoxide Dismutase / Mitogen Activated Protein Kinase / NADPH oxidase / Chromones / Superoxides / Tyrosine Kinase / Superoxide Dismutase / Mitogen Activated Protein Kinase / NADPH oxidase / Chromones / Superoxides / Tyrosine Kinase

Angiotensin II induces MMP 2 activity via FAK/JNK pathway in human endothelial cells

Cell Signaling / Cardiovascular disease / Humans / Vascular endothelium / Protein Tyrosine Kinase / Signal Transduction Pathway Models / Phosphorylation / Biochemical / Tyrosine Kinase Inhibitor / Endothelial cell / Antisense Oligonucleotide Drugs / Chromones / Angiotensin II / Protein Kinase Inhibitors / Biochemistry and cell biology / Focal Adhesion Kinase / Matrix Metalloproteinase / Tyrosine Kinase / Signal Transduction Pathway Models / Phosphorylation / Biochemical / Tyrosine Kinase Inhibitor / Endothelial cell / Antisense Oligonucleotide Drugs / Chromones / Angiotensin II / Protein Kinase Inhibitors / Biochemistry and cell biology / Focal Adhesion Kinase / Matrix Metalloproteinase / Tyrosine Kinase

Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

Cancer / Flow Cytometry / Evaluation / Cell Cycle / DNA damage / Cell line / Humans / Mice / Female / Animals / Phosphorylation / Histones / Colon cancer / Protein Kinase / Ionizing Radiation / Cell Cycle Arrest / Chromones / Tumor Growth / Therapeutic Use / Protein Kinase Inhibitors / Colorectal Neoplasms / DNA double strand breaks / Etoposide / Cell line / Humans / Mice / Female / Animals / Phosphorylation / Histones / Colon cancer / Protein Kinase / Ionizing Radiation / Cell Cycle Arrest / Chromones / Tumor Growth / Therapeutic Use / Protein Kinase Inhibitors / Colorectal Neoplasms / DNA double strand breaks / Etoposide

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

Mass Spectrometry / Humans / Mice / Animals / High Pressure Liquid Chromatography / Transfection / Camptothecin / Chromones / Transfection / Camptothecin / Chromones

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

Mass Spectrometry / Humans / Mice / Animals / High Pressure Liquid Chromatography / Transfection / Camptothecin / Chromones / Transfection / Camptothecin / Chromones

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