Vascular Endothelial Cell-Specific NF-B Suppression Attenuates Hypertension-Induced Renal Damage

Circulation Research Volume 101 Number 3 August 3, 2007

Editorials

Online supplementary information Online movie files Available at http://circres.ahajournals.org

Editorial Transitions Eduardo Marba´n ьььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь

217

Crosstalk Between Cytotoxic T-Lymphocyte–Associated Antigen-4 and Interleukin-12 in Cytotoxic T-Lymphocyte–Mediated Myocarditis: Adding Another Link to the Chain Seema S. Ahuja, Carlos A. Estrada, Merry L. Lindsey ьььььььььььььььььььььььььььььььььььььььььььььььь

218

Brain Mechanisms Contributing to Sympathetic Hyperactivity and Heart Failure Frans H.H. Leenen ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь

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The NOX on Pulmonary Hypertension Karl A. Sanders, John R. Hoidal ьььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь

224

Endothelial NF-␬B As a Mediator of Kidney Damage: The Missing Link Between Systemic Vascular and Renal Disease? Tomasz J. Guzik, David G. Harrison ьььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь

227

Periostin: More Than Just an Adhesion Molecule Thomas K. Borg, Roger Markwald ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь 230 New Targeted Angiogenic Strategy: Bursting Bubbles Tomosaburo Takahashi, Hiroaki Matsubara ьььььььььььььььььььььььььььььььььььььььььььььььььььььььь

232

Review Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall Ravi M. Rao, Lin Yang, Guillermo Garcia-Cardena, Francis W. Luscinskas ьььььььььььььььььььььььььььььь

234

Molecular Medicine CTLA-4 Ablation and Interleukin-12–Driven Differentiation Synergistically Augment Cardiac Pathogenicity of Cytotoxic T Lymphocytes Victoria A. Love, Nir Grabie, Paurene Duramad, George Stavrakis, Arlene Sharpe, Andrew Lichtman ььььььььь 248 Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature Manish Mittal, Markus Roth, Peter Ko¨nig, Simone Hofmann, Eva Dony, Parag Goyal, Anne-Christin Selbitz, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Grazyna Kwapiszewska, Wolfgang Kummer, Walter Klepetko, Mir Ali Reza Hoda, Ludger Fink, Jo¨rg Ha¨nze, Werner Seeger, Friedrich Grimminger, Harald H.H.W. Schmidt, Norbert Weissmann ьььььььььььььььььььььььььььььььььььььььььььььььььььььььь 258 Vascular Endothelial Cell–Specific NF-␬B Suppression Attenuates Hypertension-Induced Renal Damage Norbert Henke, Ruth Schmidt-Ullrich, Ralf Dechend, Joon-Keun Park, Fatimunnisa Qadri, Maren Wellner, Michael Obst, Volkmar Gross, Rainer Dietz, Friedrich C. Luft, Claus Scheidereit, Dominik N. Muller ььььььььь

268

Myocardial Smad4 Is Essential for Cardiogenesis in Mouse Embryos Lanying Song, Wensheng Yan, Xinbin Chen, Chu-xia Deng, Qin Wang, Kai Jiao ьььььььььььььььььььььььььь

277

CIRCULATION RESEARCH (ISSN 0009-7330) is published semimonthly except one issue per month in January and December and three issues per month in April and September by Lippincott Williams & Wilkins, at 12107 Insurance Way, Hagerstown, MD 21740. Business offices are located at 227 East Washington Square, Philadelphia, PA 19106-3780. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. Individuals may subscribe for their personal use at the following annual rates: Domestic: $240 for members and $399 for nonmembers. International: $297 for members of an American Heart Association scientific council and $499 for nonmembers. Contact Lippincott Williams & Wilkins for single copy rates and subscription rates for medical professionals in training and for libraries, reading rooms, and other multiple-use institutions. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to CIRCULATION RESEARCH, American Heart Association, Lippincott Williams & Wilkins, 12107 Insurance Way, Hagerstown, MD 21740.

Cellular Biology Vascular Progenitor Cells Isolated From Human Embryonic Stem Cells Give Rise to Endothelial and Smooth Muscle–Like Cells and Form Vascular Networks In Vivo Lino S. Ferreira, Sharon Gerecht, Hester F. Shieh, Nicki Watson, Maria A. Rupnick, Susan M. Dallabrida, Gordana Vunjak-Novakovic, Robert Langer ььььььььььььььььььььььььььььььььььььььььььььььььььььььььь

286

Integrative Physiology Therapeutic Arteriogenesis by Ultrasound-Mediated VEGF165 Plasmid Gene Delivery to Chronically Ischemic Skeletal Muscle Howard Leong-Poi, Michael A. Kuliszewski, Michael Lekas, Matthew Sibbald, Krystyna Teichert-Kuliszewska, Alexander L. Klibanov, Duncan J. Stewart, Jonathan R. Lindner ьььььььььььььььььььььььььььььььььььььььь

295

Central Gene Transfer of Interleukin-10 Reduces Hypothalamic Inflammation and Evidence of Heart Failure in Rats After Myocardial Infarction Yang Yu, Zhi-Hua Zhang, Shun-Guang Wei, Yi Chu, Robert M. Weiss, Donald D. Heistad, Robert B. Felder ььь

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Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling Toru Oka, Jian Xu, Robert A. Kaiser, Jaime Melendez, Michael Hambleton, Michelle A. Sargent, Angela Lorts, Eric W. Brunskill, Gerald W. Dorn II, Simon J. Conway, Bruce J. Aronow, Jeffrey Robbins, Jeffery D. Molkentin ьььь

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UltraRapid Communication Identification of Pathways for Atherosclerosis in Mice: Integration of Quantitative Trait Locus Analysis and Global Gene Expression Data Susanna S. Wang, Eric E. Schadt, Hui Wang, Xuping Wang, Leslie Ingram-Drake, Weibin Shi, Thomas A. Drake, Aldons J. Lusis Web Site Feature ьььььььььььььььььььььььььььььььььььььььььь夝e11– e30 Abstract ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь

322

Letter to the Editor Nonbone Marrow-Derived Endothelial Progenitor Cells: What Is Their Exact Location? Su¨leyman Ergu¨n, Ursula M. Gehling Web Site Feature ьььььььььььььььььььььььььььььььььььььььььььььь夝e31

On the cover: Periostin upregulation and deposition (green) in a mouse heart after myocardial infarction. Myocytes are shown in red. See related article, page 313.