Structural and charge requirements for antimicrobial peptide insertion into biological and model membranes
Descripción
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ttz!11t7î1,12t1íiig Table 9.,l lvfain charircteristics of some representiltive antirnicrobial peptides
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Sequence
Source
a-helicirl
Melittin
G IGAVLKVLTTGLPALI S!7IKRKRQQ.AIn
lvfagirinin 2
G IGKFLHSAKKFG KAFVGEIì\,fN S
Tèmporin A
FLPLIGRVLSGIL.Am
Cecropin A
KITKLFKKIEKVGQNIRDGI KAGPAVAVVGQATQIAK-Am
Apis mellifera (honey bee venom) Xenopus Lreuls (ciawed toad skin) Rana temporciria ( European retl irog skin) Hy alophor a cecr opia ( moth )
Protegrin- 1 Tachyplesin- i
RGGRLClYCTRRRFCT VC2VGR-Am KWCiFRVC2YRCICTYRRCIR-Am
Polyphemusin- I
RRWCIFRVC2 YRGFC2YRKC 1R-Am
Androctonin
RSVCIRQIKIC2RRRGGC:YYKC ITNRPY
Drosomycin
DCILSGRyKcpC2AVìTDNETCTRRVC4KEEGRSSG HCZSPSLKCTWCIEGC r
Hamster defensin (HANP- 1 ) Human B-clefensin I Sapecin B
VTC 1FCzRRRGC]ASRERHIGYC2RFGNTIYRLC]C IRR DHYNCIVSSGCQC2LYSAC]PI Ff KIQGTCzYRGKAKCl CTK LTC1EIDRSLCzLLHC]RLKGYLRAYC ISQQKVC2RCsVQ
B-'hcct
Cystine-rich
Unusual Indolicidin compt-lsition Histatin-5 Bactenecin-5
PR-39
Porcine leukocyres Tachy pleus gr.qas( As ian hcrrseshoe crab) Limults polypherruts (Atlantic horseshoe crab) Androc ronrs au"str alis (scorpion hemolymph)
'(
Dr oso phik melano gaster (fruit fly) Hanìster neutrophils Several human tissues Sorcophaga peregrina (flesh fly)
ILPWK\7PW\7PWRR-Am
Bovine neutrophils
DSHAKRHHGYKRKFHEKHHSHRGY RFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLGPFP RRRPRPPYLPRPRPPPFFPPRLPPRI PPGFPPRFPPRFP.Am
Human saliva bovine neutrophils Pig intestine
Nrltc - A r n i n . l i c a t * s r r n r r m i . l l t c . l C - t e r r n i n u s ; s u h s c r i p t n u m l . e r s r e p r c s en t a m i n o irciJs that are joined hy .lisulii.le briclgcs.
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