Structural and charge requirements for antimicrobial peptide insertion into biological and model membranes

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ttz!11t7î1,12t1íiig Table 9.,l lvfain charircteristics of some representiltive antirnicrobial peptides

C/ass

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Source

a-helicirl

Melittin

G IGAVLKVLTTGLPALI S!7IKRKRQQ.AIn

lvfagirinin 2

G IGKFLHSAKKFG KAFVGEIì\,fN S

Tèmporin A

FLPLIGRVLSGIL.Am

Cecropin A

KITKLFKKIEKVGQNIRDGI KAGPAVAVVGQATQIAK-Am

Apis mellifera (honey bee venom) Xenopus Lreuls (ciawed toad skin) Rana temporciria ( European retl irog skin) Hy alophor a cecr opia ( moth )

Protegrin- 1 Tachyplesin- i

RGGRLClYCTRRRFCT VC2VGR-Am KWCiFRVC2YRCICTYRRCIR-Am

Polyphemusin- I

RRWCIFRVC2 YRGFC2YRKC 1R-Am

Androctonin

RSVCIRQIKIC2RRRGGC:YYKC ITNRPY

Drosomycin

DCILSGRyKcpC2AVìTDNETCTRRVC4KEEGRSSG HCZSPSLKCTWCIEGC r

Hamster defensin (HANP- 1 ) Human B-clefensin I Sapecin B

VTC 1FCzRRRGC]ASRERHIGYC2RFGNTIYRLC]C IRR DHYNCIVSSGCQC2LYSAC]PI Ff KIQGTCzYRGKAKCl CTK LTC1EIDRSLCzLLHC]RLKGYLRAYC ISQQKVC2RCsVQ

B-'hcct

Cystine-rich

Unusual Indolicidin compt-lsition Histatin-5 Bactenecin-5

PR-39

Porcine leukocyres Tachy pleus gr.qas( As ian hcrrseshoe crab) Limults polypherruts (Atlantic horseshoe crab) Androc ronrs au"str alis (scorpion hemolymph)

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Dr oso phik melano gaster (fruit fly) Hanìster neutrophils Several human tissues Sorcophaga peregrina (flesh fly)

ILPWK\7PW\7PWRR-Am

Bovine neutrophils

DSHAKRHHGYKRKFHEKHHSHRGY RFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLGPFP RRRPRPPYLPRPRPPPFFPPRLPPRI PPGFPPRFPPRFP.Am

Human saliva bovine neutrophils Pig intestine

Nrltc - A r n i n . l i c a t * s r r n r r m i . l l t c . l C - t e r r n i n u s ; s u h s c r i p t n u m l . e r s r e p r c s en t a m i n o irciJs that are joined hy .lisulii.le briclgcs.

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