Seguimiento clínico y ecográfico a 1 año del EStudio PIloto de Derivación de pacientes con Espondiloartritis Precoz (ESPIDEP)

Reumatol Clin. 2011;7(4):230–235

Volumen 6, Número 1

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Genética del Lupus eritematoso generalizado New Drugs for Rheumatoid Arthritis: The Industry Point of View

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Hiperlaxitud ligamentosa en población escolar Daño en pacientes cubanos con lupus eritematoso sistémico Fibromialgia: percepción de pacientes sobre su enfermedad Actualización Consenso SER de terapias biológicas en AR

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Estrategias terapéuticas en el síndrome antifosfolipídico Fármacos en el embarazo y contracepción en enfermedades reumáticas

Artículo especial

Gripe A: Recomendaciones SER

Resonancia de raquis completo (págs. 49-52)

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Original article

One year clinical and ultrasonographic follow up of the Pilot Study for the Referral of Patients with Early Spondyloarthritis (ESPIDEP) Tatiana Cobo-Ibáñez,a,* Santiago Muñoz-Fernández,a Eugenio De Miguel,b Jesús Díez Sebastián,c Martina Steiner,a Emilio Martín-Molab Sección de Reumatología, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain Sección de Bioestadística, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain

a

b c

article info

abstract

Article history: Received September 5, 2010 Accepted November 25, 2010

Objectives: To characterize a cohort of early spondyloarthritis (SpA) patients, to demonstrate the usefulness of enthesis ultrasonography for the diagnosis and follow up, and to develop a statistical model to predict persitent activity. Patients and methods: A 1 year prospective study with clinical, radiological and ultrasonographic evaluations was performed in patients with SpA from the Pilot Study for the Referral of Patients with Early SpA (ESPIDEP). Enthesis ultrasonography was explored by the MAdrid Sonographic Enthesis Index (MASEI), and its diagnostic utility was determined to be a cutoff score of ≥18 points. The clinical, radiological and MASEI scores were studied. Finally, a statistical model from factors predicting persitent activity was developed. Results: A 1 year follow-up of 32 patients was carried out. The baseline MASEI reached a sensitivity and specificity of 78.12% and 84.37% respectively, positive and negative predictive value was 83.3% and 79.41% respectively, and positive and negative likelihood ratios were 5 and 0.26, respectively. The improvement of BASMI and the MASEI scores were significant (P=.001 and P=.007, respectively). From the beginning, women had more peripheral affectation, and men had higher axial radiological progression and higher CRP (P