*3.5 Revised Manuscript (Unmarked) Click here to view linked References
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Response to an exercise intervention after endometrial cancer: Differences between
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obese and non-obese survivors
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Basen-Engquist K1, Carmack C1, Brown J2, Jhingran A3, Baum G1, Song J4, Scruggs S1, Swartz
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MC1, Cox MG1, Lu KH2
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Departments of Behavioral Science1, Gynecologic Oncology and Reproductive Medicine2,
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Radiation Oncology3, and Biostatistics4, University of Texas MD Anderson Cancer Center
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Corresponding Author:
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Karen Basen-Engquist, PhD, MPH
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Dept of Behavioral Science
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UT MD Anderson Cancer Center
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Box 301439, Unit 1330
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Houston, TX 77230-1439
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Email:
[email protected]
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Telephone: 713-745-3123
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Fax: 713-745-4286
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The study supported by R01 CA 109919, R25T CA057730, R25E CA056452, P30 CA016672
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(PROSPR Shared Resource) and the Center for Energy Balance in Cancer Prevention and
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Survivorship, Duncan Family Institute for Cancer Prevention and Risk Assessment.
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ABSTRACT
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Objective: The objective of this paper is to describe baseline differences between obese and
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non-obese endometrial cancer survivor in anthropometrics, exercise behavior, fitness, heart rate
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and blood pressure, and quality of life, and to analyze whether the effect of a home-based
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exercise intervention on these outcomes differed for obese and non-obese participants.
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Methods: One hundred post-treatment Stage I-IIIa endometrial cancer survivors participated in
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a single arm 6 month study in which they received a home-based exercise intervention.
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Cardiorespiratory fitness, anthropometrics, and exercise behavior were measured every two
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months, and quality of life (QOL) and psychological distress were measured at baseline and 6
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months.
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Results: Adjusting for potential confounders, at baseline obese survivors had poorer
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cardiorespiratory fitness (p=.002), higher systolic blood pressure (p=.018), and lower physical
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functioning (p
