Poster, Lenguaje en Demencia frontotemporal

(n=26)I


Consensus Diagnosis /Management plan


Geriatrics, Internal Medicine, Neurology, Psychiatry and Neuropsychology.
Additional Language assessment by a clinical linguist.


DTFbv n= 10
68-76 y/o; MMSE: 29-30


SD n= 5;
59-65 y/o MMSE 14-25


PPA n= 10;
51-75 y/o MMSE 13-26












































Early Language decline in Frontotemporal dementia in a Colombian Study : Suggesting a study of differences across languages
Ángela Martínez1,3,Diana Matallana1,2, Pablo Reyes1,2, Fréderique Gayraud3
1 Aging Institute, Medical School, Pontificia Universidad Javeriana, Colombia; 2 San Ignacio Hospital, Pontificia Universidad Javeriana, Colombia; 3 Laboratoire Dynamique du Langage, Université Lumière Lyon 2, France
BACKROUND
Language impairment may be an important diagnosis criteria between bvFTD, SD and PPA in cases in witch patients share some early psychiatric and cognitive symptoms.
Linguistic variants of FTD, are defined as clinical syndromes characterized by a progressive loss of language functions with a poor language expression, difficulties in naming and comprehension of words and sentences, with preservation of memory and daily activities.
Behavioural variant of the FTD is a clinical syndrome characterized by a progressive deterioration personality, social comportment and cognition (specially executive functions).
Memory Clinic, San Ignacio Hospital, Colombia.
Additional language tests:
BAT : Bilingual Aphasia Test (translinguistic characteristics of the study)
Spontaneous speech sample (transcribed using the CHAT format, and analyzed using the CLAN programs), in witch we will analyse lexical, discursive and fluency variables.


METHODS : procedure
Index of difficulties according to syntactic structures (summary of comprehension and production)
Results: The first analysis was descriptive, summary measures are described as frequencies (Figure 1) and percentages. (Figure 2). In addition a hierarchical clustering of the method of squared Euclidean distances was done, where the nearest clinical neighbor were identified. The analysis was run with 3 sets of variables. a) BAT (100%), b) errors in BAT, c) spontaneous speech.
DISCUSSION
We will research on Spanish and French patients, including all language possible variables will allow to identify translinguistic differences.
Deep Language analysis is useful when heterogeneity w/groups is present and depends (in all groups) on the disease stage. PPA patients had the worse performance.
When patients with different variant are together they share language compromise and such closeness are much more frequent in (PPA-DS groups).
Procedure used lead changes in the protocol rating transcription as well as spontaneous speech variables.
bvFTD had more difficulties to understand negative sentences (Written and oral the dog does not bite the cat); APP and DS had also compromised relative, passive, and affirmative sentences.
bvFTD executive passive structure difficulty is associated with executive functions: The inability to represent a temporal sequence of the phrase –not understanding if.. Then).
RESULTS
LINGUISTIC COMPLEXITY
Narrative structures
Sentences
Reading keeping stimuli
Reading
Reading
Reading
Listening w/o seeing
Listening
Listening
Listening
Listening
Table 1. BAT RESULTS. CA: Auditive comprehension of narrative structures, LS: Reading comprehension of narrative structures, CF: copying sentences, DF: sentences dictation , CES: syntactic structures comprehension, CO: sentence production, JG: grammatical judgement, DAV: Auditive word comprehension, LF: simple sentence reading.
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(n=26)I
Consensus Diagnosis /Management plan
DTFbv n= 10
68-76 y/o; MMSE: 29-30
SD n= 5;
59-65 y/o MMSE 14-25
PPA n= 10;
51-75 y/o MMSE 13-26
Geriatrics, Internal Medicine, Neurology, Psychiatry and Neuropsychology.
Additional Language assessment by a clinical linguist.