Intramuscular dexmedetomidine premedication-an alternative to midazolam-fentanyl-combination in elective hysterectomy?

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Anoeslhesiol Scond 1994: 38: 238-243 Prinled in Denmark all rights ruserued Atla

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Anaeslhcsiol .&and

I994

Acta Anaesthesiologica Scandinavica

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ISSN 0001-51 72

Intramuscular dexmedetomidine premedication an alternative to midazolam-fentanylcombination in elective hysterectomy?

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M.-L. JAAKOLA, J. KANTO,H. SCHEININ and A. KALLIO Department of Anaesthesiology, Turku University Hospital, Orion Corporation Farmos R&D, Turku, Finland

Sedation, anxiolysis, intubation responses and fentanyl anaesthetic requirements were investigated in a double-blind, randomized study in twenty ASA 1-11 elective hysterectomy patients. Ten patients received dexmedetomidine 2.5 pg kg- i.m. 60 min before induction and saline placebo i.v. 2 min prior to induction ( = D P group). Ten patients received midazolam 0.08 mg kg-' i.m. 60 min and fentanyl 1.5 pg kg-l i.v. ( = M F group) 2 min before induction of anaesthesia with thiopentone 4 mg kg- '. Anaesthesia was maintained with 70% nitrous oxide in oxygen and with fentanyl 2 pg kg-' i.v. increments according to predetermined criteria. Both premedications induced sedation (P