Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes

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Author's personal copy Journal of Ethnopharmacology 126 (2009) 238–243

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Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes Adejuwon Adewale Adeneye a,b,∗ , Olufunmilayo Olaide Adeyemi b,∗∗ a b

Department of Pharmacology, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria Department of Pharmacology, College of Medicine, University of Lagos, Idi-Araba, Lagos State, Nigeria

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Article history: Received 24 March 2009 Received in revised form 19 August 2009 Accepted 22 August 2009 Available online 31 August 2009 Keywords: Hunteria umbellata (K. Schum) Hallier f. Experimental diabetes Antihyperglycaemia Antihyperlipidaemia Fasting insulin indices

a b s t r a c t Ethnopharmacological relevance: In African traditional medicine, water decoction made from the dry seeds of Hunteria umbellata (K. Schum) Hallier f. is highly valued in the management of diabetes mellitus. Aim: In the present study, the antihyperglycaemic activity of the seed aqueous extract of Hunteria umbellate (K. Schum) Hallier f. (HU) was investigated in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats. Materials and methods: Alloxan-induced, dexamethasone-induced and high fructose-induced hyperglycaemic rats were treated with single, daily oral administration of 1 mg/kg of glibenclamide, 50 mg/kg, 100 mg/kg and 200 mg/kg of HU in Groups III, IV, V and VI, for 14 days, 21 days and 8 weeks, respectively. The effects of these drugs on FBG, free plasma insulin levels, HbA1c , serum TG and TC, and insulin resistance indices were investigated. Results: Data generated in the current study showed that glibenclamide and graded oral doses of HU caused significant dose related (p < 0.05,