ACTH-independent hyperadrenocorticism due to food-dependent hypercortisolemia in a dog: A case report

Available online at www.sciencedirect.com

The Veterinary Journal The Veterinary Journal 177 (2008) 141–143 www.elsevier.com/locate/tvjl

Short Communication

ACTH-independent hyperadrenocorticism due to food-dependent hypercortisolemia in a dog: A case report S. Galac

a,*

, V.J. Kars a, G. Voorhout b, J.A. Mol a, H.S. Kooistra

a

a

b

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, P.O. Box 80.154, 3508 TD Utrecht, The Netherlands Division of Diagnostic Imaging, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, P.O. Box 80.154, 3508 TD Utrecht, The Netherlands Accepted 4 April 2007

Abstract In addition to adrenocortical tumours, aberrant expression of functional hormone receptors in the adrenal cortex may cause adrenocorticotrophic hormone (ACTH)-independent hyperadrenocorticism. Here we report on a 6 year old Vizsla dog in which ACTH-independent hyperadrenocorticism was associated with meal-induced hypercortisolemia. Diagnosis was based on history, physical findings, biochemical changes, and elevation of the urinary corticoid/creatinine ratio (UCCR) on two consecutive days (11 and 8.3 · 10 6, reference range