A single intrauterine infusion of sustained recombinant ovine interferon-τ extends corpus luteum lifespan in cyclic ewes

September 15, 2017 | Autor: Lien Huynh | Categoría: Theriogenology, Biological Sciences, Sustained Release Matrix Tablet, Delivery System, Corpus Luteum
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A SINGLE INTRAUTERINE INFUSION OF SUSTAINED RECOMBINANT OVINE INTERFERON-z EXTENDS CORPUS LUTEUM LIFESPAN IN CYCLIC EWES

R. M. L’Haridon,’ L. Huynh,’ N. E. Assal ’ and J. Martal ’

‘Unite de Virologie et Immunologie ‘Unite d’Endocrinologie de I’Embryon Institut National de la Recherche Agronomique (INRA) 78 350. Jouy en Josas, France Received for publication: Accepted:

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February

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1995

ABSTRACT

Delivery carriers were developped to permit sustained r-elease of recombinant ovine tau-interferon (roIFN-z) to increase corpus luteum (CL) lifespan in cyclic ewes following a single intrauterine administration on Day 10 post e&us. A single infusion with 1.7mg roIFN-r covalently bound to carboxymethyl biogel agarose (carbodiimide coupling) significantly increased the interestrus interval (P
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