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cyclic GMP
cyclic GMP
Compartmentalized Phosphodiesterase-2 Activity Blunts -Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway
Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol
Guanylyl Cyclase-Linked Receptors
Neuroscience / Cognitive Science / Humans / Animals / Neurosciences / Guanylate Cyclase / cyclic GMP / Guanylate Cyclase / cyclic GMP
Compartmentalized Phosphodiesterase-2 Activity Blunts -Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway
Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol
Differential inhibition of mesangial MAP kinase cascade by cyclic nucleotides
Enzyme Inhibitors / Signal Transduction / Protein Kinases / Kidney / cyclic AMP / Animals / Peptides / Mitogen Activated Protein Kinase / Clinical Sciences / Rats / Cyclic nucleotides / Endothelin-1 / MAP Kinase / cyclic GMP / Animals / Peptides / Mitogen Activated Protein Kinase / Clinical Sciences / Rats / Cyclic nucleotides / Endothelin-1 / MAP Kinase / cyclic GMP
Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists
Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP
Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors
Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Dogs / Humans / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure
Androgens Regulate Phosphodiesterase Type 5 Expression and Functional Activity in Corpora Cavernosa
Endocrinology / Immunohistochemistry / Gene expression / Real-time RT-PCR / Western blotting / Biological Sciences / Humans / Testosterone / Female / Animals / Male / Androgens / Prostate / Penis / tESTIS / Enzyme / Phosphodiesterase Inhibitors / Late onset hypogonadism / Western blot / Protein Expression / Rabbits / Epididymis / Female To Male / Level / cyclic GMP / Biological Sciences / Humans / Testosterone / Female / Animals / Male / Androgens / Prostate / Penis / tESTIS / Enzyme / Phosphodiesterase Inhibitors / Late onset hypogonadism / Western blot / Protein Expression / Rabbits / Epididymis / Female To Male / Level / cyclic GMP
Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension
Treatment Outcome / Pulmonary Hypertension / Blood Pressure / Nitric oxide / Animals / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Vascular Resistance / Atrial Natriuretic Factor / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Vascular Resistance / Atrial Natriuretic Factor
Genistein from Flemingia vestita (Fabaceae) enhances NO and its mediator (cGMP) production in a cestode parasite, Raillietina echinobothrida
Parasitology / Nitric oxide / Animals / PARALYSIS / Plant extracts / POULTRY DISEASES / Nitric Oxide Synthase / Fabaceae / Time Factors / Cestode infections / Cestoda / Veterinary Sciences / Genistein / Anthelmintics / Praziquantel / cyclic GMP / POULTRY DISEASES / Nitric Oxide Synthase / Fabaceae / Time Factors / Cestode infections / Cestoda / Veterinary Sciences / Genistein / Anthelmintics / Praziquantel / cyclic GMP
Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase
Catalysis / Science / Inflammation / Multidisciplinary / Signal Transduction / Inflammatory Immune Response / Peroxidase / Humans / Mutation / Mice / Nitric oxide / Animals / Vascular endothelium / Cattle / Hydrogen Peroxide / ENDOTOXEMIA / Rats / Transfection / Aorta / Vasodilation / Oxidation-Reduction / Leukocytes / Myeloperoxidase / cyclic GMP / Host Defense / Inflammatory Immune Response / Peroxidase / Humans / Mutation / Mice / Nitric oxide / Animals / Vascular endothelium / Cattle / Hydrogen Peroxide / ENDOTOXEMIA / Rats / Transfection / Aorta / Vasodilation / Oxidation-Reduction / Leukocytes / Myeloperoxidase / cyclic GMP / Host Defense
Acute stress delays brain mitochondrial permeability transition pore opening
Neurochemistry / Calcium / Signal Transduction / Brain / Permeability / Animals / Male / Rats / Wistar Rats / Oxygen Consumption / Neurosciences / Glucocorticoids / cyclic GMP / Animals / Male / Rats / Wistar Rats / Oxygen Consumption / Neurosciences / Glucocorticoids / cyclic GMP
cGMP stimulates endoplasmic reticulum Ca2+-ATPase in vascular endothelial cells
Life Sciences / Enzyme Inhibitors / Animals / Male / Cell Death / Endoplasmic Reticulum / Vascular endothelium / Calcium Signaling / Alkaloids / Rats / Endothelial cell / cyclic GMP / Biochemistry and cell biology / Adenosine Triphosphate / Cell Growth / Sarcoplasmic reticulum / Endoplasmic Reticulum / Vascular endothelium / Calcium Signaling / Alkaloids / Rats / Endothelial cell / cyclic GMP / Biochemistry and cell biology / Adenosine Triphosphate / Cell Growth / Sarcoplasmic reticulum
Plasma cyclic nucleotide levels in acute leukemia patients
Leukemia / Adolescent / Acute Myeloid Leukemia / Humans / cyclic AMP / Female / Blood / Male / Clinical Sciences / Aged / Middle Aged / Adult / Cyclic nucleotides / cyclic GMP / Female / Blood / Male / Clinical Sciences / Aged / Middle Aged / Adult / Cyclic nucleotides / cyclic GMP
Plasma cyclic nucleotide levels in acute leukemia patients
Leukemia / Adolescent / Acute Myeloid Leukemia / Humans / cyclic AMP / Female / Blood / Male / Clinical Sciences / Aged / Middle Aged / Adult / Cyclic nucleotides / cyclic GMP / Female / Blood / Male / Clinical Sciences / Aged / Middle Aged / Adult / Cyclic nucleotides / cyclic GMP
Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase
Vascular biology / Cercopithecus aethiops / Humans / Endothelial Cells / Mice / Nitric oxide / Animals / Vascular endothelium / Acetylcholine / Phosphorylation / Vasoconstriction / Superoxide Dismutase / NADPH oxidase / Clinical Sciences / Cattle / Endothelial cell / Transfection / Vasodilation / Superoxides / cyclic GMP / Nitric oxide / Animals / Vascular endothelium / Acetylcholine / Phosphorylation / Vasoconstriction / Superoxide Dismutase / NADPH oxidase / Clinical Sciences / Cattle / Endothelial cell / Transfection / Vasodilation / Superoxides / cyclic GMP
Compartmentalized Phosphodiesterase-2 Activity Blunts -Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway
Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol
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