Vascular endothelial growth factor receptor - Page 3

Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Humans / Cancer Therapy / Mice / Animals / Isoenzymes / Medicinal / Neoplasms / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor / Mice / Animals / Isoenzymes / Medicinal / Neoplasms / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor

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Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency

Wound Healing / Signal Transduction / Endothelial Cells / Mice / Animals / Male / Clinical Sciences / Time Factors / Cell Proliferation / Vascular endothelial growth factor receptor / Down-Regulation / Male / Clinical Sciences / Time Factors / Cell Proliferation / Vascular endothelial growth factor receptor / Down-Regulation

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Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

Signal Transduction / Humans / Mice / Endocytosis / Animals / Male / Cell Proliferation / Clinical Investigation / Vascular endothelial growth factor receptor / Male / Cell Proliferation / Clinical Investigation / Vascular endothelial growth factor receptor

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Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Pharmacokinetics / Macromolecular X-Ray Crystallography / Cell line / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor

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Vascular endothelial growth factor C—a potent risk factor in childhood acute lymphoblastic leukaemia: an immunocytochemical approach

Immunohistochemistry / Treatment Outcome / Adolescent / Humans / Child / Histopathology / Acute Lymphoblastic Leukaemia / Risk factors / Clinical Sciences / Bone Marrow Transplantation / Prognosis / Risk Factors / Bone Marrow Cells / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor / Histopathology / Acute Lymphoblastic Leukaemia / Risk factors / Clinical Sciences / Bone Marrow Transplantation / Prognosis / Risk Factors / Bone Marrow Cells / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor

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7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity

Organic Chemistry / Mice / Animals / Drug Design / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor

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Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Pharmacokinetics / Macromolecular X-Ray Crystallography / Cell line / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor

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MicroRNAs Control Vascular Endothelial Growth Factor Signaling

Humans / Endothelial Cells / Female / Animals / Male / Clinical Sciences / microRNAs / Circulation / Vascular endothelial growth factor receptor / Clinical Sciences / microRNAs / Circulation / Vascular endothelial growth factor receptor

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Blockade of Vascular Endothelial Growth Factor Suppresses Experimental Restenosis After Intraluminal Injury by Inhibiting Recruitment of Monocyte Lineage Cells

Nephrology / Oncology / Urology / Immunology / Cancer / Treatment / Immunohistochemistry / Cornea / Immunology of the Gut / Apoptosis / Pancreatic Cancer / Multidisciplinary / Cell Division / Signal Transduction / Microvascular Physiology / Complication / Humans / Cancer Therapy / Lasers / Epidermal Growth Factor/ErbB receptors / Reactive Oxygen Species / Mice / Stress response / Animals / Male / Squamous Cell Carcinoma / Immunotherapy / Vascular endothelium / Protein Tyrosine Kinase / Fibroblast Growth Factor / Diabetic Nephropathy / Clinical Sciences / Epidermal Growth Factor Receptor / Optometry and Ophthalmology / Tyrosine Kinase Inhibitor / Photochemotherapy / Endothelial cell / Public health systems and services research / Model System / Neoplasms / Pyridines / Kidney Disease / Circulation / Blood Vessels / Albuminuria / Ionizing Radiation / Lymph Node / Type 2 Diabetes Mellitus / Antitumor Activity / Growth Factor / Vascular Endothelial Function / Glomerular Basement Membrane / Blood Vessel / Protein Kinase Inhibitors / Lymphatic System / Nude mice / Neutralizing antibodies / Gene Transfer / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor / Receptor Tyrosine Kinase / Phthalazines / Treatment / Immunohistochemistry / Cornea / Immunology of the Gut / Apoptosis / Pancreatic Cancer / Multidisciplinary / Cell Division / Signal Transduction / Microvascular Physiology / Complication / Humans / Cancer Therapy / Lasers / Epidermal Growth Factor/ErbB receptors / Reactive Oxygen Species / Mice / Stress response / Animals / Male / Squamous Cell Carcinoma / Immunotherapy / Vascular endothelium / Protein Tyrosine Kinase / Fibroblast Growth Factor / Diabetic Nephropathy / Clinical Sciences / Epidermal Growth Factor Receptor / Optometry and Ophthalmology / Tyrosine Kinase Inhibitor / Photochemotherapy / Endothelial cell / Public health systems and services research / Model System / Neoplasms / Pyridines / Kidney Disease / Circulation / Blood Vessels / Albuminuria / Ionizing Radiation / Lymph Node / Type 2 Diabetes Mellitus / Antitumor Activity / Growth Factor / Vascular Endothelial Function / Glomerular Basement Membrane / Blood Vessel / Protein Kinase Inhibitors / Lymphatic System / Nude mice / Neutralizing antibodies / Gene Transfer / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor / Receptor Tyrosine Kinase / Phthalazines

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7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity

Organic Chemistry / Cancer / Mice / Animals / Drug Design / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Aurora B / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Aurora B

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Tumor Endothelium-specific Transgene Expression Directed by Vascular Endothelial Growth Factor Receptor2 (Flk-1) Promoter/Enhancer Sequences1,2

Cancer / Gene expression / Transgenic Mice / Epidermal Growth Factor/ErbB receptors / Mice / Female / Animals / Male / Vascular endothelium / Fibrosarcoma / Specific Activity / Transgene Expression / Blood Vessel / Adenocarcinoma / Vascular endothelial growth factor receptor / Receptor Tyrosine Kinase / Female / Animals / Male / Vascular endothelium / Fibrosarcoma / Specific Activity / Transgene Expression / Blood Vessel / Adenocarcinoma / Vascular endothelial growth factor receptor / Receptor Tyrosine Kinase

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