RNA interference

A Genetic Screen Identifies PITX1 as a Suppressor of RAS Activity and Tumorigenicity

Transcription Factors / Biological Sciences / RNA interference / Cell line / Humans / Genetic Testing / Mice / Animals / Cell / Genetic Screening / Phenotype / Caco-2 cells / Tumor Suppressor Gene / Colon cancer / HeLa cells / Gene Expression Regulation / Genetic Testing / Mice / Animals / Cell / Genetic Screening / Phenotype / Caco-2 cells / Tumor Suppressor Gene / Colon cancer / HeLa cells / Gene Expression Regulation

Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype

Genetics / Stem Cells / Human Embryonic Stem Cells / RNA silencing / RNA polymerase / Multidisciplinary / Nature / Cell Division / Genetic Engineering / RNA interference / Cell line / Humans / Mice / Animals / Phenotype / Gene Function / Gene Targeting / Homologous Recombination / Embryos / ES cell / Multidisciplinary / Nature / Cell Division / Genetic Engineering / RNA interference / Cell line / Humans / Mice / Animals / Phenotype / Gene Function / Gene Targeting / Homologous Recombination / Embryos / ES cell

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

Skeletal muscle biology / Diabetes / Membrane Proteins / RNA interference / Insulin Resistance / Cell line / Mice / Electroporation / Female / Animals / Gene transfer techniques / Male / Lipid metabolism / Rats / Oxidative phosphorylation / Wistar Rats / Recombinant Proteins / Gene expression profiling / Cell line / Mice / Electroporation / Female / Animals / Gene transfer techniques / Male / Lipid metabolism / Rats / Oxidative phosphorylation / Wistar Rats / Recombinant Proteins / Gene expression profiling

RNA Interference Suppression of Genes in Glycosyl Transferase Families 43 and 47 in Wheat Starchy Endosperm Causes Large Decreases in Arabinoxylan Content

Polysaccharides / Biological Sciences / RNA interference / Phylogeny / Plant Genome Project / Plant Physiology / Glycosyltransferases / Xylans / Cell Wall / Triticum / Plant Physiology / Glycosyltransferases / Xylans / Cell Wall / Triticum

A “Twist box” Code of p53 Inactivation: Twist box:p53 Interaction Promotes p53 Degradation

Epithelial-Mesenchymal Transition / RNA interference / Humans / Mice / Animals / Sarcoma / Phosphorylation / Cancer Cell / Neurosciences / Sarcoma / Phosphorylation / Cancer Cell / Neurosciences

Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells

DNA damage / Apoptosis / RNA interference / Humans / Data Collection / Biochemical / Colon cancer / Biological Process / BIOCHEMICAL PHARMACOLOGY / Human Fibroblasts / Antineoplastic Agents / Biochemical / Colon cancer / Biological Process / BIOCHEMICAL PHARMACOLOGY / Human Fibroblasts / Antineoplastic Agents

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

Multidisciplinary / Nature / RNA interference / Humans / Mice / Animals / Alternative splicing / Chromatin / Alternative Splicing / Ribonucleoproteins / Animals / Alternative splicing / Chromatin / Alternative Splicing / Ribonucleoproteins

In Vivo RNAi Rescue in Drosophila melanogaster with Genomic Transgenes from Drosophila pseudoobscura

Genomics / Drosophila melanogaster / Multidisciplinary / Cell Culture / RNA interference / Drosophila / Animals / PLoS one / Biological Process / Large Scale / Species Specificity / Base Sequence / Drosophila / Animals / PLoS one / Biological Process / Large Scale / Species Specificity / Base Sequence

Silencing of HIV-1 genes using siRNA-expressing genetic constructs

Genetics / Molecular Biology / Gene Therapy / RNA interference / Biochemistry and cell biology

Long-term XPC Silencing Reduces DNA Double-Strand Break Repair

Genetics / Cancer / DNA replication / Gamma Rays / DNA damage / DNA repair / Gene expression / Gene Silencing / RNA interference / Humans / Nuclear Structure / Nucleotide Excision Repair / Spectrum / HeLa cells / DNA binding proteins / DNA repair / Gene expression / Gene Silencing / RNA interference / Humans / Nuclear Structure / Nucleotide Excision Repair / Spectrum / HeLa cells / DNA binding proteins

Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett’s esophagus

Immunohistochemistry / Transcription Factors / Biopsy / Western blotting / Transcriptome / RNA interference / Humans / Female / Oncogene / Male / Gene Regulatory Networks / Clinical Sciences / Aged / Middle Aged / Epithelium / Cell Proliferation / Adenocarcinoma / Endoscopes / RNA interference / Humans / Female / Oncogene / Male / Gene Regulatory Networks / Clinical Sciences / Aged / Middle Aged / Epithelium / Cell Proliferation / Adenocarcinoma / Endoscopes

DNA supercoiling factor contributes to dosage compensation in Drosophila

Transcription Factors / Development / Biological Sciences / RNA interference / Drosophila / Animals / Male / Chromatin / Histone acetyltransferases / X chromosome / Calcium Binding Proteins / Dosage compensation / Gene Expression Regulation / Immunoblotting / Animals / Male / Chromatin / Histone acetyltransferases / X chromosome / Calcium Binding Proteins / Dosage compensation / Gene Expression Regulation / Immunoblotting

A viral transcription factor exhibits antiviral RNA silencing suppression activity independent of its nuclear localization

Tobacco / Transcription Factors / Biological Sciences / RNA interference / Mutation / Plant viruses / microRNAs / Plant Leaves / Plant viruses / microRNAs / Plant Leaves

Neuroblastoma-targeted Nanoparticles Entrapping siRNA Specifically Knockdown ALK

Technology / Nanoparticles / Gene Silencing / Western blotting / Biological Sciences / Molecular / RNA interference / Cell line / Humans / Mice / Animals / Cell Death / Neuroblastoma / Delivery System / Anaplastic Lymphoma Kinase (ALK) / Transfection / Side Effect / Antitumor Activity / Molecular Targeted Therapy / Receptor Tyrosine Kinase / Cell Growth / Molecular / RNA interference / Cell line / Humans / Mice / Animals / Cell Death / Neuroblastoma / Delivery System / Anaplastic Lymphoma Kinase (ALK) / Transfection / Side Effect / Antitumor Activity / Molecular Targeted Therapy / Receptor Tyrosine Kinase / Cell Growth

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

Genetics / Caenorhabditis elegans / Enzyme Inhibitors / Apoptosis / Gene expression / Caspases / RNA interference / Humans / Germ Cells / Mutagenesis / Animals / Neoplasms / Cancer Cell / Calcium Binding Proteins / Antineoplastic Agents / Neurosciences / Caspases / RNA interference / Humans / Germ Cells / Mutagenesis / Animals / Neoplasms / Cancer Cell / Calcium Binding Proteins / Antineoplastic Agents / Neurosciences

miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells

Multidisciplinary / Signal Transduction / RNA interference / Cell line / Cell Differentiation / Humans / PLoS one / microRNAs / Hepatocytes / Humans / PLoS one / microRNAs / Hepatocytes
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