Pyrazoles

Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

Enzyme Inhibitors / Biological Sciences / Humans / Protein Kinases / Escherichia coli / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure

COX-2 suppresses tissue factor expression via endocannabinoid-directed PPAR activation

Nuclear Receptor / Humans / Endothelial Cells / Mice / Animals / Vascular endothelium / Endothelial cell / Experimental Medicine / Side Effect / Endocannabinoids / Pyrazoles / Tissue Factor / Vascular endothelium / Endothelial cell / Experimental Medicine / Side Effect / Endocannabinoids / Pyrazoles / Tissue Factor

Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase

Gastroenterology / Membrane Proteins / Cell Division / Humans / Gastric Cancer / Phosphorylation / Mitogen Activated Protein Kinase / Clinical Sciences / Isoenzymes / DNA binding / Western blot / Antisense Oligonucleotide Drugs / Protein Kinase / Pyrazoles / Neurosciences / Prostaglandin E2 / Cell Growth / Phosphorylation / Mitogen Activated Protein Kinase / Clinical Sciences / Isoenzymes / DNA binding / Western blot / Antisense Oligonucleotide Drugs / Protein Kinase / Pyrazoles / Neurosciences / Prostaglandin E2 / Cell Growth

Canonical Transient Receptor Potential 3 Channel Triggers Vascular Endothelial Growth Factor-Induced Intracellular Ca 2+ Oscillations in Endothelial Progenitor Cells Isolated from Umbilical Cord Blood

Technology / Stem Cells / Calcium / Signal Transduction / Biological Sciences / RNA interference / Humans / Endothelial Cells / Female / Young Adult / Anti-inflammatory agents / Middle Aged / Adult / Cell Proliferation / Pyrazoles / Ion Transport / RNA interference / Humans / Endothelial Cells / Female / Young Adult / Anti-inflammatory agents / Middle Aged / Adult / Cell Proliferation / Pyrazoles / Ion Transport

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

Organic Chemistry / Mice / Animals / Drug Design / Amino Acids / Rats / Amino Acid Profile / Molecular Conformation / Seizures / Pyrazoles / Neuroprotective Agents / Rats / Amino Acid Profile / Molecular Conformation / Seizures / Pyrazoles / Neuroprotective Agents

Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility

British / Nitriles / Female / Animals / Male / Vasoconstriction / Phenols / Rats / Time Factors / Wistar Rats / Pyrazoles / Mesenteric Arteries / Estradiol / Estrogen receptor-beta / Selective estrogen receptor modulators / Estrogen receptor alpha / Vasoconstriction / Phenols / Rats / Time Factors / Wistar Rats / Pyrazoles / Mesenteric Arteries / Estradiol / Estrogen receptor-beta / Selective estrogen receptor modulators / Estrogen receptor alpha

Central pharmacological activity of a new piperazine derivative: 4-(1-Phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester

Animal Behavior / Life Sciences / Serotonin / Mice / Animals / Male / Sleep / Time Factors / Pyrazoles / Maze Learning / Pentobarbital / Biochemistry and cell biology / Flumazenil / Male / Sleep / Time Factors / Pyrazoles / Maze Learning / Pentobarbital / Biochemistry and cell biology / Flumazenil

Lipopolysaccharide Induces Cyclooxygenase-2 in Intestinal Epithelium via a Noncanonical p38 MAPK Pathway

Immunology / Fluorescence Microscopy / Enzyme Inhibitors / Immunology of the Gut / Western blotting / Animals / The / Lipopolysaccharides / Rats / Transfection / Pyrazoles / Enterocytes / Animals / The / Lipopolysaccharides / Rats / Transfection / Pyrazoles / Enterocytes

Lipopolysaccharide Induces Cyclooxygenase-2 in Intestinal Epithelium via a Noncanonical p38 MAPK Pathway

Immunology / Fluorescence Microscopy / Enzyme Inhibitors / Immunology of the Gut / Western blotting / Animals / The / Lipopolysaccharides / Rats / Transfection / Pyrazoles / Enterocytes / Animals / The / Lipopolysaccharides / Rats / Transfection / Pyrazoles / Enterocytes

Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N′-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides

Organic Chemistry / Leishmania / Leishmaniasis / Mice / Animals / European / Pyrazoles / Structure activity Relationship / Cell Survival / Molecular Structure / European / Pyrazoles / Structure activity Relationship / Cell Survival / Molecular Structure

A Novel Antimycobacterial Compound Acts as an Intracellular Iron Chelator

Microbiology / Medical Microbiology / Siderophores / Iron / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pyrazoles / Microbial Sensitivity Tests / Pyrazoles

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

Organic Chemistry / Mice / Animals / Drug Design / Amino Acids / Rats / Amino Acid Profile / Molecular Conformation / Seizures / Pyrazoles / Neuroprotective Agents / Rats / Amino Acid Profile / Molecular Conformation / Seizures / Pyrazoles / Neuroprotective Agents

Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist

Organic Chemistry / Pharmaceutical Chemistry / Mice / Animals / Drug Design / Molecular Conformation / Bioorganic and medicinal Chemistry / Pyrazoles / CB 1 receptor / Piperidines / Molecular Conformation / Bioorganic and medicinal Chemistry / Pyrazoles / CB 1 receptor / Piperidines

Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

Enzyme Inhibitors / Biological Sciences / Humans / Protein Kinases / Escherichia coli / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure

Avances en el tratamiento anticoagulante oral de la fibrilación auricular

Treatment Outcome / Stroke / Humans / Atrial Fibrillation / Anticoagulants / Warfarin / Pyridines / Pyrazoles / Benzimidazoles / Thiazoles / Medicina Clinica / Embolism / Warfarin / Pyridines / Pyrazoles / Benzimidazoles / Thiazoles / Medicina Clinica / Embolism

ENP11, a potential CB1R antagonist, induces anorexia in rats

Pain / Animals / Male / Pain Perception / Hyperphagia / Feeding Behavior / Eating / Body Temperature / Rats / Body Weight / Wistar Rats / Postural Balance / Endocannabinoids / Pyrazoles / Piperidines / Feeding Behavior / Eating / Body Temperature / Rats / Body Weight / Wistar Rats / Postural Balance / Endocannabinoids / Pyrazoles / Piperidines

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