Prodrugs | DATOSPDF

Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: Protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid

Oncology / Toxicology / Molecular Medicine / Cancer / Archives / Cytokines / Cell Cycle / Inflammation / Oxidative Stress / Apoptosis / Lung Inflammation / Lipids / Fibrinogen / Prodrugs / Keratinocytes / Liver / Endothelial Cells / Mice / Cholesterol / Vehicle Emissions / Female / Animals / Cell / Pneumonia / Male / Systemic inflammation / Animal Model / Brain Ischemia / Gene / Lung / Triglycerides / Dep / Neutrophils / Lipopolysaccharides / Peripheral Vascular Disease / Lysine / Particle Size / Respiratory System / Respiratory Tract Infections / Particulate Matter / Body Weight / Gasoline / Chemokines / Murine Model / Health Effect / Bleeding Time / Vascular Permeability / Particulate Air Pollution / Pulmonary disease / Aspartate Aminotransferases / Air Pollutants / Microvessels / Pulmonary Edema / Interleukin / Bronchoalveolar lavage / Alanine Transaminase / Inflammatory response / Random Allocation / Cytokines / Cell Cycle / Inflammation / Oxidative Stress / Apoptosis / Lung Inflammation / Lipids / Fibrinogen / Prodrugs / Keratinocytes / Liver / Endothelial Cells / Mice / Cholesterol / Vehicle Emissions / Female / Animals / Cell / Pneumonia / Male / Systemic inflammation / Animal Model / Brain Ischemia / Gene / Lung / Triglycerides / Dep / Neutrophils / Lipopolysaccharides / Peripheral Vascular Disease / Lysine / Particle Size / Respiratory System / Respiratory Tract Infections / Particulate Matter / Body Weight / Gasoline / Chemokines / Murine Model / Health Effect / Bleeding Time / Vascular Permeability / Particulate Air Pollution / Pulmonary disease / Aspartate Aminotransferases / Air Pollutants / Microvessels / Pulmonary Edema / Interleukin / Bronchoalveolar lavage / Alanine Transaminase / Inflammatory response / Random Allocation

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Polyaspartamide-Doxorubicin Conjugate as Potential Prodrug for Anticancer Therapy

Polyamines / Prodrugs / Humans / Pharmaceutical / Female / Animals / Breast / Doxorubicin / Aspartame / Animals / Breast / Doxorubicin / Aspartame

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Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide

Leishmania / Dendrimers / Prodrugs / Humans / Drug Design / Molecular Diversity / Chagas disease / Molecular Conformation / Structure activity Relationship / Molecular Structure / Molecular Diversity / Chagas disease / Molecular Conformation / Structure activity Relationship / Molecular Structure

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Lipase-catalyzed esterification of (S)-naproxen ethyl ester in supercritical carbon dioxide

Technology / Water / Carbon Dioxide / Catalysis / Biological Sciences / Prodrugs / Microbiology and Biotechnology / Industrial microbiology / Temperature / Esterification / Pressure / Time Factors / Solutions / Naproxen / Esters / Lipase / Prodrugs / Microbiology and Biotechnology / Industrial microbiology / Temperature / Esterification / Pressure / Time Factors / Solutions / Naproxen / Esters / Lipase

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Pharmacokinetic evaluation of indomethacin ethyl ester-loaded nanoencapsules

Pharmaceutics / Prodrugs / Animals / Male / Nanocapsules / Rats / Biotransformation / Wistar Rats / Drug Compounding / Indomethacin / Rats / Biotransformation / Wistar Rats / Drug Compounding / Indomethacin

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Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucoma

Pharmacology / Quantum Physics / Calcium / Pharmacokinetics / Cornea / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma

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Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma

Pharmacology / Quantum Physics / Calcium / Pharmacokinetics / Cornea / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma

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Identification of 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl]-N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration

Organic Chemistry / Enzyme Inhibitors / Prodrugs / Humans / Animals / Male / Solubility / Rats / Edema / Fever / Foot / Wistar Rats / Carrageenan / Water soluble polymers / Bioorganic and medicinal Chemistry / Structure activity Relationship / Hyperalgesia / Endotoxins / Molecular Structure / Male / Solubility / Rats / Edema / Fever / Foot / Wistar Rats / Carrageenan / Water soluble polymers / Bioorganic and medicinal Chemistry / Structure activity Relationship / Hyperalgesia / Endotoxins / Molecular Structure

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Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs

Organic Chemistry / Medical Microbiology / Cell line / Hepatitis B / Prodrugs / Humans / Mutation / Mice / Female / Animals / Male / Rats / Bioorganic and medicinal Chemistry / Antiviral / Hepatitis B virus / Antiviral Activity / Transgenic Mouse Technology / Nucleotides / Antiviral Agents / Humans / Mutation / Mice / Female / Animals / Male / Rats / Bioorganic and medicinal Chemistry / Antiviral / Hepatitis B virus / Antiviral Activity / Transgenic Mouse Technology / Nucleotides / Antiviral Agents

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Acetylsalicylic acid as a potential regulator of prolidase-convertible pro-drugs in control and neoplastic cells

Medical Microbiology / Prodrugs / Humans / Cell Death / Aspirin / Enzyme / Acetylsalicylic Acid / Thin Layer Chromatography / Antineoplastic Agents / C-DNA Synthesis / Breast Cancer Cells / Enzyme / Acetylsalicylic Acid / Thin Layer Chromatography / Antineoplastic Agents / C-DNA Synthesis / Breast Cancer Cells

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Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase

Functional Analysis / Molecular Microbiology / Molecular Genetics / Gene expression / Plant Secondary metabolite / Biological Sciences / Molecular / Virulence / Prodrugs / Mutagenesis / Botrytis / Oxidoreductases / Laccase / Secondary Metabolites / Plant Pathogen interaction / Phenols / Botrytis cinerea / Stilbenes / Antifungal Agents / Vitis / Amino Acid Sequence / Base Sequence / Arachis Hypogaea / Host Plant / Plant Leaves / Biological Sciences / Molecular / Virulence / Prodrugs / Mutagenesis / Botrytis / Oxidoreductases / Laccase / Secondary Metabolites / Plant Pathogen interaction / Phenols / Botrytis cinerea / Stilbenes / Antifungal Agents / Vitis / Amino Acid Sequence / Base Sequence / Arachis Hypogaea / Host Plant / Plant Leaves

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Prodrugs Design Based on Inter- and Intramolecular Chemical Processes

Catalysis / Ab initio calculations / Prodrugs / Drug Design / Shell Half-Life / Design of Prodrugs / DFT Calculations / Biocompatible Materials / Polyethylene Glycols / Biochemistry and cell biology / Design of Prodrugs / DFT Calculations / Biocompatible Materials / Polyethylene Glycols / Biochemistry and cell biology

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Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs

Organic Chemistry / Prodrugs / Animals / Molecules / Rats / Oximes / Antifungal Agents / Oximes / Antifungal Agents

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Statistical Model To Evaluate In Vivo Activities of Antimalarial Drugs in a Plasmodium cynomolgi-Macaque Model for Plasmodium vivax Malaria

Microbiology / Medical Microbiology / Drug development / Prodrugs / Mixed Effects Models / Female / Animals / Drug Resistance / Male / Animal Model / South America / Animal Experimentation / Antimalarials / Rhesus macaques / Antimicrobial agents / Macaca Mulatta / Sub Saharan Africa / Statistical Model / Mechanism of action / Host Range / Plasmodium Vivax / Treatment Effect / Female / Animals / Drug Resistance / Male / Animal Model / South America / Animal Experimentation / Antimalarials / Rhesus macaques / Antimicrobial agents / Macaca Mulatta / Sub Saharan Africa / Statistical Model / Mechanism of action / Host Range / Plasmodium Vivax / Treatment Effect

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Esters of valerenic acid as potential prodrugs

Animal Behavior / Anxiety / Xenopus / Prodrugs / Animals / Male / Sesquiterpenes / ANXIETY / Seizures / Oocytes / Esters / Pentylenetetrazole / Male / Sesquiterpenes / ANXIETY / Seizures / Oocytes / Esters / Pentylenetetrazole

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Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase

Functional Analysis / Molecular Microbiology / Molecular Genetics / Gene expression / Plant Secondary metabolite / Biological Sciences / Molecular / Virulence / Prodrugs / Mutagenesis / Botrytis / Oxidoreductases / Laccase / Secondary Metabolites / Plant Pathogen interaction / Phenols / Botrytis cinerea / Stilbenes / Antifungal Agents / Vitis / Amino Acid Sequence / Base Sequence / Arachis Hypogaea / Host Plant / Plant Leaves / Biological Sciences / Molecular / Virulence / Prodrugs / Mutagenesis / Botrytis / Oxidoreductases / Laccase / Secondary Metabolites / Plant Pathogen interaction / Phenols / Botrytis cinerea / Stilbenes / Antifungal Agents / Vitis / Amino Acid Sequence / Base Sequence / Arachis Hypogaea / Host Plant / Plant Leaves

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