Molecular Targeted Therapy - Page 3

215. Investigating Urokinase Plasminogen Activator Receptor (CD87), as a Potential Target for Non-Viral Gene Transfer

Pharmacology / Technology / Biological Sciences / Cell line / Molecular Targeted Therapy / Gene Transfer / Binding affinity / Gene Transfer / Binding affinity

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Neuroblastoma-targeted Nanoparticles Entrapping siRNA Specifically Knockdown ALK

Pharmacology / Technology / Nanoparticles / Gene Silencing / Western blotting / Biological Sciences / Molecular / RNA interference / Cell line / Humans / Mice / Animals / Therapy / Cell Death / Neuroblastoma / Delivery System / Anaplastic Lymphoma Kinase (ALK) / Transfection / Side Effect / Antitumor Activity / Molecular Targeted Therapy / Receptor Tyrosine Kinase / Cell Growth / Biological Sciences / Molecular / RNA interference / Cell line / Humans / Mice / Animals / Therapy / Cell Death / Neuroblastoma / Delivery System / Anaplastic Lymphoma Kinase (ALK) / Transfection / Side Effect / Antitumor Activity / Molecular Targeted Therapy / Receptor Tyrosine Kinase / Cell Growth

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DNA-Loaded Bacterial Ghosts Efficiently Mediate Reporter Gene Transfer and Expression in Macrophages

Pharmacology / Technology / Flow Cytometry / Fluorescence Microscopy / Macrophages / Gene expression / Biological Sciences / DNA / Cell line / Escherichia coli / Mice / Animals / Gene transfer techniques / Plasmids / Gram-negative bacteria / Confocal Laser Scanning Microscopy / Recombinant Proteins / Molecular Targeted Therapy / Plasmid DNA / Gene Transfer / Gene expression / Biological Sciences / DNA / Cell line / Escherichia coli / Mice / Animals / Gene transfer techniques / Plasmids / Gram-negative bacteria / Confocal Laser Scanning Microscopy / Recombinant Proteins / Molecular Targeted Therapy / Plasmid DNA / Gene Transfer

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45. Adenoviral Gene Transfer of SERCA2a Restores Mechanical and Energetic Left-Ventricular Function in Spontaneously Diabetic Rats

Technology / Biological Sciences / Blood Glucose / Left Ventricular Function / Diastolic Dysfunction/CHF / Diabetic Rat / Oxygen Consumption / Molecular Targeted Therapy / Gene Transfer / Sarcoplasmic reticulum / Diabetic Rat / Oxygen Consumption / Molecular Targeted Therapy / Gene Transfer / Sarcoplasmic reticulum

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237. Gene Expression Profiles in Diabetic Cardiomyopathy Following SERCA2a Gene Transfer

Pharmacology / Technology / Transcription Regulation / Gene expression / Biological Sciences / Global change / Heart Failure / Gene ontology / Chip / Rat Model / Type II Diabetes / Molecular Targeted Therapy / Intracellular Signaling / Gene Transfer / Sarcoplasmic reticulum / Global change / Heart Failure / Gene ontology / Chip / Rat Model / Type II Diabetes / Molecular Targeted Therapy / Intracellular Signaling / Gene Transfer / Sarcoplasmic reticulum

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Lentiviral Vector Gene Transfer into Fetal Rhesus Monkeys (Macaca mulatta): Lung-Targeting Approaches

Pharmacology / Genetics / Technology / Flow Cytometry / Fluorescence Microscopy / Immunohistochemistry / Ultrasound / HIV / Biological Sciences / Molecular / Hematopoietic Stem Cells / Humans / Animals / Blood sampling / Gene transfer techniques / Polymerase Chain Reaction / Lung / Rhesus Monkey / Model System / Macaca Mulatta / Transgene Expression / Molecular Targeted Therapy / Enzyme Linked Immunosorbent Assay / Gene Transfer / Immunohistochemistry / Ultrasound / HIV / Biological Sciences / Molecular / Hematopoietic Stem Cells / Humans / Animals / Blood sampling / Gene transfer techniques / Polymerase Chain Reaction / Lung / Rhesus Monkey / Model System / Macaca Mulatta / Transgene Expression / Molecular Targeted Therapy / Enzyme Linked Immunosorbent Assay / Gene Transfer

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Blocking Free Radical Production via Adenoviral Gene Transfer Decreases Cardiac Ischemia–Reperfusion Injury

Technology / Free Radicals / Gene expression / Western blotting / Free Radical / Biological Sciences / Molecular / Ischemia Reperfusion Injury / Antioxidants / Animals / Heart / Catalase / Glutathione Peroxidase / Enzyme / Hydrogen Peroxide / Antioxidant Activity / Myocardium / Blood Flow / Transfection / Rabbits / Molecular Targeted Therapy / Gene Transfer / Biological Sciences / Molecular / Ischemia Reperfusion Injury / Antioxidants / Animals / Heart / Catalase / Glutathione Peroxidase / Enzyme / Hydrogen Peroxide / Antioxidant Activity / Myocardium / Blood Flow / Transfection / Rabbits / Molecular Targeted Therapy / Gene Transfer

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Extensive Ex Vivo Expansion of Functional Human Erythroid Precursors Established From Umbilical Cord Blood Cells by Defined Factors

Pharmacology / Genetics / Technology / Genomics / Stem Cells / Cytokines / Biological Sciences / Cell Differentiation / Humans / Hormones / Cluster Analysis / Red Blood Cells / Karyotype / Erythropoiesis / Cell Proliferation / Molecular Targeted Therapy / Diploidy / Hemoglobins / Gene Expression Regulation / Gene expression profiling / Cytokines / Biological Sciences / Cell Differentiation / Humans / Hormones / Cluster Analysis / Red Blood Cells / Karyotype / Erythropoiesis / Cell Proliferation / Molecular Targeted Therapy / Diploidy / Hemoglobins / Gene Expression Regulation / Gene expression profiling

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Deficiency of caveolin-1 in Apcmin/+ mice promotes colorectal tumorigenesis

Signal Transduction / Humans / Mice / Animals / Carcinogenesis / Adenomatous Polyposis-coli / Caveolin-1 / Molecular Targeted Therapy / Adenomatous Polyposis-coli / Caveolin-1 / Molecular Targeted Therapy

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SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

Technology / Confocal Microscopy / Western blotting / Biological Sciences / Heart Failure / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation / Coronary artery / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation / Coronary artery

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Prolonged Biologically Active Transgene Expression Driven by HSV Latency Active Promoter 2 (LAP2) in Brain In Vivo

Pharmacology / Technology / Gene Therapy / Gene expression / Biological Sciences / Molecular / Brain / Low Dose / Mice / Chronic Disease / Female / Animals / Therapy / Substantia nigra / Rats / Biological activity / Transgene Expression / Molecular Targeted Therapy / Parkinson Disease / Herpes Simplex Virus / Molecular / Brain / Low Dose / Mice / Chronic Disease / Female / Animals / Therapy / Substantia nigra / Rats / Biological activity / Transgene Expression / Molecular Targeted Therapy / Parkinson Disease / Herpes Simplex Virus

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45. Adenoviral Gene Transfer of SERCA2a Restores Mechanical and Energetic Left-Ventricular Function in Spontaneously Diabetic Rats

Technology / Biological Sciences / Blood Glucose / Left Ventricular Function / Diastolic Dysfunction/CHF / Diabetic Rat / Oxygen Consumption / Molecular Targeted Therapy / Gene Transfer / Sarcoplasmic reticulum / Diabetic Rat / Oxygen Consumption / Molecular Targeted Therapy / Gene Transfer / Sarcoplasmic reticulum

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SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

Technology / Confocal Microscopy / Western blotting / Biological Sciences / Heart Failure / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation / Coronary artery / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation / Coronary artery

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Correction of Laminin-5 Deficiency in Human Epidermal Stem Cells by Transcriptionally Targeted Lentiviral Vectors

Genetics / Technology / Stem Cells / Gene Therapy / Health / Stem Cell / Gene expression / Biological Sciences / Molecular / Cell Differentiation / Humans / Keratinocytes / Basement Membrane / Mice / Animals / Epidermolysis Bullosa / Lentivirus / Epidermis / Transgene Expression / Molecular Targeted Therapy / Gene Transfer / Cell Adhesion Molecules / Tissue Specificity / Skin Biopsy / Stem Cell / Gene expression / Biological Sciences / Molecular / Cell Differentiation / Humans / Keratinocytes / Basement Membrane / Mice / Animals / Epidermolysis Bullosa / Lentivirus / Epidermis / Transgene Expression / Molecular Targeted Therapy / Gene Transfer / Cell Adhesion Molecules / Tissue Specificity / Skin Biopsy

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Dual human epidermal growth factor receptor 2 blockade

Signal Transduction / Humans / Female / Quinolines / Molecular Targeted Therapy / Quinazolines / Clinical Trials as Topic / Quinazolines / Clinical Trials as Topic

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Adrenal Cancer: Clinical Advances

Endocrinology / Humans / Medical Oncology / Animals / Carcinoma / Prognosis / Molecular Targeted Therapy / Prognosis / Molecular Targeted Therapy

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