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Medicinal
Novel tetracyclic spiropiperidines. 3. 1-Arylspiro[indoline-3,4\'-piperidine]s as potential antidepressants
Organic Chemistry / Medicinal Chemistry / Humans / Animals / Medicinal / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine
Characterization of a Designed Vascular Endothelial Growth Factor Receptor Antagonist Helical Peptide with Antiangiogenic Activity in Vivo
Organic Chemistry / Water / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Signal Transduction / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival
Characterization of a Designed Vascular Endothelial Growth Factor Receptor Antagonist Helical Peptide with Antiangiogenic Activity in Vivo
Organic Chemistry / Water / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Signal Transduction / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival
Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists
Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP
2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 2
Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents
2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 1
Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents
2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 2
Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents
2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 1
Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents
Genotoxic Evaluation of Mikania laevigata Extract on DNA Damage Caused by Acute Coal Dust Exposure
Nutrition and Dietetics / Coal / DNA damage / Liver / Femur / Animals / Blood / Male / Bone marrow / Comet Assay / Plant extracts / Rats / Hepatocytes / Medicinal / Group / Wistar Rats / Food Sciences / Medicinal Food / Dust / Organic Compound / Environmental Exposure / Control Group / Animals / Blood / Male / Bone marrow / Comet Assay / Plant extracts / Rats / Hepatocytes / Medicinal / Group / Wistar Rats / Food Sciences / Medicinal Food / Dust / Organic Compound / Environmental Exposure / Control Group
Genotoxic Evaluation of Mikania laevigata Extract on DNA Damage Caused by Acute Coal Dust Exposure
Nutrition and Dietetics / Coal / DNA damage / Liver / Femur / Animals / Blood / Male / Bone marrow / Comet Assay / Plant extracts / Rats / Hepatocytes / Medicinal / Group / Wistar Rats / Food Sciences / Medicinal Food / Dust / Organic Compound / Environmental Exposure / Control Group / Animals / Blood / Male / Bone marrow / Comet Assay / Plant extracts / Rats / Hepatocytes / Medicinal / Group / Wistar Rats / Food Sciences / Medicinal Food / Dust / Organic Compound / Environmental Exposure / Control Group
Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists
Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP
Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators
Organic Chemistry / Medicinal Chemistry / Kinetics / Enzyme Inhibitors / Cell line / Humans / Mice / Animals / Drug Design / Medicinal / Neoplasms / Structure activity Relationship / Biological Availability / Antineoplastic Agents / Humans / Mice / Animals / Drug Design / Medicinal / Neoplasms / Structure activity Relationship / Biological Availability / Antineoplastic Agents
Fancy Bioisosteres: Novel Paracyclophane Derivatives As Super-Affinity Dopamine D3 Receptor Antagonists
Organic Chemistry / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Dopamine / Humans / Mutation / Animals / Amides / Swine / Radioligand Assay / Medicinal / Molecular Conformation / Structure activity Relationship / Mutation / Animals / Amides / Swine / Radioligand Assay / Medicinal / Molecular Conformation / Structure activity Relationship
A Novel Cell-Penetrating Peptide Sequence Derived by Structural Minimization of a Snake Toxin Exhibits Preferential Nucleolar Localization
Organic Chemistry / Medicinal Chemistry / Snake venoms / Humans / Animals / HeLa cells / Medicinal / Amino Acid Sequence / Protein Transport / HeLa cells / Medicinal / Amino Acid Sequence / Protein Transport
Phytochemical properties and in-vitro antifungal activity of Senna alata Linn. crude stem bark extract
Medicinal
5-Benzylidene 1,2-Dihydrochromeno[3,4- f ]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists
Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Progesterone / Humans / Female / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus / Ovariectomy / Female / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus / Ovariectomy
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