Ligands

Diet-Derived Polyphenol Metabolite Enterolactone Is a Tissue-Specific Estrogen Receptor Activator

Endocrinology / Diet / Gene expression / Cell Culture / Estrogen Receptor / Nuclear Receptor / Biological Sciences / Cell line / Humans / Mice / Animals / Lignans / Ligand Binding / Transcription Factor / Cell nucleus / Ligands / Phytoestrogen / Butyrolactone / Estrogen receptor-beta / Tissue Specificity / Estrogen receptor alpha / Nuclear Receptor / Biological Sciences / Cell line / Humans / Mice / Animals / Lignans / Ligand Binding / Transcription Factor / Cell nucleus / Ligands / Phytoestrogen / Butyrolactone / Estrogen receptor-beta / Tissue Specificity / Estrogen receptor alpha

Copper Complexes of Nicotinic-Aromatic Carboxylic Acids as Superoxide Dismutase Mimetics

Organic Chemistry / Fungi / Old Copper Complex / Copper / Bacteria / Superoxide Dismutase / Polycyclic aromatic hydrocarbons (PAHs) / Molecules / Biomimetic materials / Microbial Sensitivity Tests / Carboxylic Acids / Ligands / Superoxides / Superoxide Dismutase / Polycyclic aromatic hydrocarbons (PAHs) / Molecules / Biomimetic materials / Microbial Sensitivity Tests / Carboxylic Acids / Ligands / Superoxides

Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents

Organic Chemistry / Fluorescence Resonance Energy Transfer / Cell Culture / In Vitro / Virus / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands

Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents

Organic Chemistry / Fluorescence Resonance Energy Transfer / Cell Culture / In Vitro / Virus / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands

Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents

Organic Chemistry / Fluorescence Resonance Energy Transfer / Cell Culture / In Vitro / Virus / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands

Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents

Organic Chemistry / Fluorescence Resonance Energy Transfer / Cell Culture / In Vitro / Virus / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Chemical Synthesis / Ligands

An Iron-Based Cytosolic Catalase and Superoxide Dismutase Mimic Complex

Chemical Engineering / Inorganic Chemistry / Oxidative Stress / Inorganic / Saccharomyces cerevisiae / Antioxidants / Reactive Oxygen Species / Catalase / Iron / Superoxide Dismutase / Hydrogen Peroxide / Protein Binding / Ligands / Molecular Structure / Antioxidants / Reactive Oxygen Species / Catalase / Iron / Superoxide Dismutase / Hydrogen Peroxide / Protein Binding / Ligands / Molecular Structure

Targeting of Mitochondria-Endoplasmic Reticulum by Fluorescent Macrocyclic Compounds

Flow Cytometry / Breast Cancer / Fluorescence Microscopy / Mitochondria / Fluorescent Dyes and Reagents / Confocal Microscopy / Apoptosis / Multidisciplinary / Humans / Endoplasmic Reticulum / Fluorescence Imaging / PLoS one / Adult / Pyridines / Toxicity Tests / Mitochondrial Membrane Potential / Cell Survival / Ligands / Plasma Membrane / Breast Cancer Cells / Proof of Concept / Confocal Microscopy / Apoptosis / Multidisciplinary / Humans / Endoplasmic Reticulum / Fluorescence Imaging / PLoS one / Adult / Pyridines / Toxicity Tests / Mitochondrial Membrane Potential / Cell Survival / Ligands / Plasma Membrane / Breast Cancer Cells / Proof of Concept

An estrogen receptor chimera senses ligands by nuclear translocation

Biochemistry / Fluorescence Microscopy / Drug Discovery / Fluorescent Dyes and Reagents / STEROIDS / High Content Screening / Estrogen Receptor / Cercopithecus aethiops / Dexamethasone / Cell line / Humans / Mice / Animals / Immunoprecipitation / Tamoxifen / Time Factors / Transfection / Protein Binding / Cytoplasm / Ligands / Glucocorticoids / Estradiol / Protein Transport / Biochemistry and cell biology / High Content Screening / Estrogen Receptor / Cercopithecus aethiops / Dexamethasone / Cell line / Humans / Mice / Animals / Immunoprecipitation / Tamoxifen / Time Factors / Transfection / Protein Binding / Cytoplasm / Ligands / Glucocorticoids / Estradiol / Protein Transport / Biochemistry and cell biology

PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a New Mitochondrial Benzodiazepine-Receptor Ligand, Induces Apoptosis in C6 glioma Cells

Mitochondria / DNA damage / Apoptosis / Caspases / Glioma / Animals / Caspase / Rats / Time Factors / Receptors / Antineoplastic Agents / Ligands / Biochemistry and cell biology / Animals / Caspase / Rats / Time Factors / Receptors / Antineoplastic Agents / Ligands / Biochemistry and cell biology

TLRs as miRNA Receptors

Cancer / Toll Like Receptors / Humans / Mice / Animals / microRNAs / Protein Binding / Ligands / microRNAs / Protein Binding / Ligands

Mutagenesis of important amino acid reveals unconventional homologous internalization of β1-adrenergic receptor

Life Sciences / Western blotting / Internalization / Cell line / Humans / Mutation / cyclic AMP / D-Aspartic Acid / Lysine / Radioligand Assay / Amino Acid Profile / Transfection / Propranolol / Site-directed Mutagenesis / Ligands / Biochemistry and cell biology / Isoproterenol / Cell Membrane / Mutation / cyclic AMP / D-Aspartic Acid / Lysine / Radioligand Assay / Amino Acid Profile / Transfection / Propranolol / Site-directed Mutagenesis / Ligands / Biochemistry and cell biology / Isoproterenol / Cell Membrane

Functional Characterization and Expression of a Cytosolic Iron-Superoxide Dismutase from Cowpea Root Nodules

Physiology / Electrophysiology / British / Immunohistochemistry / Mitochondria / Gene expression / Western blotting / Free Radical / Biological Sciences / Phylogeny / Plant Physiology / Sequence alignment / Escherichia coli / Nitric oxide / Animals / Plant / Male / Vascular endothelium / American / Cyclic peptides / Iron / Medical Physiology / Soybean / Plant Roots / Superoxide Dismutase / Enzyme / Subcellular Localization / Molecular cloning / Rats / Fabaceae / Phaseolus vulgaris / Radioligand Assay / Endothelin-1 / Potassium Channels / Wistar Rats / Common bean / Amino Acid Profile / Amino Acid Sequence / Glycine max / Carotid Artery / Recombinant Proteins / Vasodilation / Ligands / Catalytic Activity / Vigna Unguiculata / PISUM SATIVUM / Piperidines / Chlorides / Endothelins / Molecular Sequence Data / Gene expression / Western blotting / Free Radical / Biological Sciences / Phylogeny / Plant Physiology / Sequence alignment / Escherichia coli / Nitric oxide / Animals / Plant / Male / Vascular endothelium / American / Cyclic peptides / Iron / Medical Physiology / Soybean / Plant Roots / Superoxide Dismutase / Enzyme / Subcellular Localization / Molecular cloning / Rats / Fabaceae / Phaseolus vulgaris / Radioligand Assay / Endothelin-1 / Potassium Channels / Wistar Rats / Common bean / Amino Acid Profile / Amino Acid Sequence / Glycine max / Carotid Artery / Recombinant Proteins / Vasodilation / Ligands / Catalytic Activity / Vigna Unguiculata / PISUM SATIVUM / Piperidines / Chlorides / Endothelins / Molecular Sequence Data

Multidimensional De Novo Design Reveals 5-HT2B Receptor-Selective Ligands

Microfluidics / Computer Aided Design / Humans / Amines / Drug Design / CHEMICAL SCIENCES / Protein Binding / Ligands / CHEMICAL SCIENCES / Protein Binding / Ligands

Transient receptor potential (TRP) channels as drug targets

Transient receptor potential channels / Drug Design / Urinary Tract / Drug Targeting / Ligands
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