In Vivo

Antimicrobial activity of Artemisia douglasiana leaf essential oil

Complementary and Alternative Medicine / Plant Biology / Treatment / Adolescent / Essential Oil / Phytotherapy / Paraplegia / Humans / Escherichia coli / Chronic Disease / Antimicrobial activity / Male / Bacteria / Staphylococcus aureus / Candida albicans / Artemisia / Urinary Tract Infections / Aspergillus niger / Antimicrobial / Pseudomonas aeruginosa / Gram Positive Bacteria / In Vivo / Gram-negative bacteria / Fitoterapia / Gas Chromatography/mass Spectrometry / Stimulation / Microbial Sensitivity Tests / Bacillus Cereus / Pseudomonas Aeruginosa / Biological activity / Plant Oils / Plant Leaves / Thallophyta / Host Defense / Spinal Dysraphism / Phytotherapy / Paraplegia / Humans / Escherichia coli / Chronic Disease / Antimicrobial activity / Male / Bacteria / Staphylococcus aureus / Candida albicans / Artemisia / Urinary Tract Infections / Aspergillus niger / Antimicrobial / Pseudomonas aeruginosa / Gram Positive Bacteria / In Vivo / Gram-negative bacteria / Fitoterapia / Gas Chromatography/mass Spectrometry / Stimulation / Microbial Sensitivity Tests / Bacillus Cereus / Pseudomonas Aeruginosa / Biological activity / Plant Oils / Plant Leaves / Thallophyta / Host Defense / Spinal Dysraphism

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In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Organic Chemistry / Medicinal Chemistry / Obesity / Pharmacokinetics / Pharmaceutical Chemistry / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity

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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification

Organic Chemistry / Pharmacokinetics / In Vitro / Humans / Animals / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides

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Long-lasting in vivo gene silencing by electrotransfer of shRNA expressing plasmid

Genetics / Skeletal muscle biology / Gene Silencing / Humans / Muscle / Mice / Electroporation / Female / Animals / shRNA / Gene / Plasmids / Green Fluorescent Protein / In Vivo / Gen / Transfection / Silencing / Plasmid / GFP / Mice / Electroporation / Female / Animals / shRNA / Gene / Plasmids / Green Fluorescent Protein / In Vivo / Gen / Transfection / Silencing / Plasmid / GFP

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Intracerebral microdialysis: I. Experimental studies of diffusion kinetics

Kinetics / Dialysis / Concentration / In Vitro / Diffusion / Animals / Method / Male / Temperature / Perfusion / Difusion / Experimental Study / High Pressure Liquid Chromatography / Microdialysis / In Vivo / Rats / Rat / Pharmacological / Brain Chemistry / Pharmacological Methods / Extracellular Space / Animals / Method / Male / Temperature / Perfusion / Difusion / Experimental Study / High Pressure Liquid Chromatography / Microdialysis / In Vivo / Rats / Rat / Pharmacological / Brain Chemistry / Pharmacological Methods / Extracellular Space

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Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle

Skeletal muscle biology / Enzyme Inhibitors / Biological Sciences / Ischemia Reperfusion Injury / Humans / Caffeine / Hemodynamics / Nitric oxide / Female / Male / Young Adult / American / Animal Model / In Vivo / Skeletal Muscle / Adult / Blood Flow / Free Fatty Acid / Vasodilatation / Glucose Uptake / Vasodilation / Healthy Subjects / Forearm / Brachial artery / Caffeine / Hemodynamics / Nitric oxide / Female / Male / Young Adult / American / Animal Model / In Vivo / Skeletal Muscle / Adult / Blood Flow / Free Fatty Acid / Vasodilatation / Glucose Uptake / Vasodilation / Healthy Subjects / Forearm / Brachial artery

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2-Arylpyrimidines: Novel CRF-1 receptor antagonists

Organic Chemistry / Depression / Kinetics / Pharmacokinetics / Pharmaceutical Chemistry / In Vitro / Humans / Animals / Drug Design / Solubility / In Vivo / Rats / Rat / Ether / Molecular Conformation / Bioorganic and medicinal Chemistry / Affinity / Structure activity Relationship / Chemical Synthesis / Molecular Structure / In Vitro / Humans / Animals / Drug Design / Solubility / In Vivo / Rats / Rat / Ether / Molecular Conformation / Bioorganic and medicinal Chemistry / Affinity / Structure activity Relationship / Chemical Synthesis / Molecular Structure

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PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo

Calcium / Membrane Proteins / Gene expression / Biological Sciences / In Vitro / Mice / Animals / Leptin / Brown Adipose Tissue / In Vivo / Adipocytes / Lipase / Protein Biosynthesis / Cycloheximide / Mice / Animals / Leptin / Brown Adipose Tissue / In Vivo / Adipocytes / Lipase / Protein Biosynthesis / Cycloheximide

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Phase transfer catalyzed synthesis of bis-quinolines: Antileishmanial activity in experimental visceral leishmaniasis and in vitro antibacterial evaluation

Organic Chemistry / Catalysis / Treatment / Transmission Electron Microscopy / In Vitro / Mice / Animals / Visceral Leishmaniasis / Methane / European / Antibacterial activity / In Vivo / Anti-Bacterial Agents / Microbial Sensitivity Tests / Quinolines / Structure activity Relationship / Chemical Synthesis / Mice / Animals / Visceral Leishmaniasis / Methane / European / Antibacterial activity / In Vivo / Anti-Bacterial Agents / Microbial Sensitivity Tests / Quinolines / Structure activity Relationship / Chemical Synthesis

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In Vitro and in Vivo Killing of Acute Lymphoblastic Leukemia Cells by L-Asparaginase1

Cancer / Flow Cytometry / Prediction / Treatment / Cytotoxicity / Cell Culture / In Vitro / Bone marrow / Enzyme / In Vivo / Biological activity / Cell Surface Markers / Propidium Iodide / Acute Lymphoblastic Leukemia / Cell Culture / In Vitro / Bone marrow / Enzyme / In Vivo / Biological activity / Cell Surface Markers / Propidium Iodide / Acute Lymphoblastic Leukemia

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In Vitro and in Vivo Killing of Acute Lymphoblastic Leukemia Cells by L-Asparaginase1

Cancer / Flow Cytometry / Prediction / Treatment / Cytotoxicity / Cell Culture / In Vitro / Bone marrow / Enzyme / In Vivo / Biological activity / Cell Surface Markers / Propidium Iodide / Acute Lymphoblastic Leukemia / Cell Culture / In Vitro / Bone marrow / Enzyme / In Vivo / Biological activity / Cell Surface Markers / Propidium Iodide / Acute Lymphoblastic Leukemia

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A semiparametric deconvolution model to establish in vivo-in vitro correlation applied to OROS oxybutynin

Modeling / Prediction / Pharmacokinetics / Pharmaceutical Chemistry / Dosage Form / In Vitro / Humans / Controlled release / Pharmaceutical Sciences / Estimation / Bioavailability / Mathematical Model / In Vivo / Linear Systems / Reproducibility of Results / Active Ingredient / Biological Availability / Enantiomer / In Vitro / Humans / Controlled release / Pharmaceutical Sciences / Estimation / Bioavailability / Mathematical Model / In Vivo / Linear Systems / Reproducibility of Results / Active Ingredient / Biological Availability / Enantiomer

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Anhydride prodrugs for nonsteroidal anti-inflammatory drugs

In Vitro / Prodrugs / Pharmaceutical / Female / Animals / Prodrug / In Vivo / Rats / Edema / Rat / Prodrug / In Vivo / Rats / Edema / Rat

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Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo

Electron Microscopy / Nanomedicine / Transmission Electron Microscopy / Nanotechnology / Tuberculosis / Mice / Female / Animals / Bacteria / TEM / Colloids / DSC / Liposomes / Pdi / Liposome / European / In Vivo / Particle Size / Size Distribution / Delivery System / Surface Properties / Surface Active Agents / Indexation / Langmuir Blodgett / Quaternary Ammonium Compounds / Monoglycerides / Drug Stability / Lipid Bilayer / Mice / Female / Animals / Bacteria / TEM / Colloids / DSC / Liposomes / Pdi / Liposome / European / In Vivo / Particle Size / Size Distribution / Delivery System / Surface Properties / Surface Active Agents / Indexation / Langmuir Blodgett / Quaternary Ammonium Compounds / Monoglycerides / Drug Stability / Lipid Bilayer

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Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones

Macrophages / Transcription Factors / Dendritic Cells / Hematopoiesis / Hematopoietic Stem Cells / Cell Differentiation / Natural Killer cells / Mice / Animals / Blood / Exploration / Clinical Sciences / In Vivo / Clone / Pax / Cell Proliferation / Erythrocytes / DNA binding proteins / Hematopoietic Stem Cell Transplantation / Cell Differentiation / Natural Killer cells / Mice / Animals / Blood / Exploration / Clinical Sciences / In Vivo / Clone / Pax / Cell Proliferation / Erythrocytes / DNA binding proteins / Hematopoietic Stem Cell Transplantation

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Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury

Biological Sciences / Mice / Vasculitis / Animals / Lead / American / Hyperplasia / In Vivo / Nitric Oxide Synthase / Deficiency / Cell Proliferation / Deficit / Wounds and Injuries / Aorta / Vascular Injury / Superoxides / Intimal hyperplasia / American / Hyperplasia / In Vivo / Nitric Oxide Synthase / Deficiency / Cell Proliferation / Deficit / Wounds and Injuries / Aorta / Vascular Injury / Superoxides / Intimal hyperplasia

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