Gene Targeting

A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X

Genomic Imprinting / Humans / Mice / Female / Animals / Male / Haemostasis and Thrombosis / Fibrosis / Behavioral Animal Models / Clinical Sciences / Mouse Model / Genotype / Myocardium / Gene Targeting / Cardiomyopathies / Amino Acid Substitution Rates / Fetal death / Male / Haemostasis and Thrombosis / Fibrosis / Behavioral Animal Models / Clinical Sciences / Mouse Model / Genotype / Myocardium / Gene Targeting / Cardiomyopathies / Amino Acid Substitution Rates / Fetal death

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice

Stem Cells / DNA damage / DNA repair / Stem Cell / Multidisciplinary / Mitosis / Cell line / Mice / Animals / Bone marrow / PLoS one / Epithelial cells / Radiation Dose / DNA damage response / Gene Targeting / Chromosome segregation / Gastrointestinal Tract / Homologous Recombination / Human Fibroblasts / Cell Cycle Proteins / Cell Survival / Radiation Tolerance / Whole Body / Functional Status / Bone Marrow Cells / Mitomycin / Mitosis / Cell line / Mice / Animals / Bone marrow / PLoS one / Epithelial cells / Radiation Dose / DNA damage response / Gene Targeting / Chromosome segregation / Gastrointestinal Tract / Homologous Recombination / Human Fibroblasts / Cell Cycle Proteins / Cell Survival / Radiation Tolerance / Whole Body / Functional Status / Bone Marrow Cells / Mitomycin

Improved Microarray-Based Decision Support with Graph Encoded Interactome Data

MicroRNA / Multidisciplinary / Protein-Protein Interaction / Humans / Decision Support / Prior Knowledge / Support vector machine / PLoS one / microRNAs / Spectral Graph Theory / Biological systems / Neoplasms / Gene Targeting / Metabolic pathway / Protein Binding / Similarity Function / Microarray Data / Gene Expression Data / Prior Knowledge / Support vector machine / PLoS one / microRNAs / Spectral Graph Theory / Biological systems / Neoplasms / Gene Targeting / Metabolic pathway / Protein Binding / Similarity Function / Microarray Data / Gene Expression Data

A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences

Biology / Gene Therapy / Medicine / Protein Engineering / Biological Sciences / DNA / Environmental Sciences / Humans / Mutation / Nucleic Acids / Substrate Specificity / DNA binding / Gene Targeting / Genome sequence / Nucleotides / Dimerization / DNA / Environmental Sciences / Humans / Mutation / Nucleic Acids / Substrate Specificity / DNA binding / Gene Targeting / Genome sequence / Nucleotides / Dimerization

GST expression mediates dopaminergic neuron sensitivity in experimental parkinsonism

Multidisciplinary / Free Radical / Dopamine / Reactive Oxygen Species / Mice / Animals / Glutathione / Detoxification / Substantia nigra / Neurons / Xenobiotics / Gene Targeting / Genetic Susceptibility / Differential expression / Animals / Glutathione / Detoxification / Substantia nigra / Neurons / Xenobiotics / Gene Targeting / Genetic Susceptibility / Differential expression

A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences

Biology / Gene Therapy / Medicine / Protein Engineering / Biological Sciences / DNA / Environmental Sciences / Humans / Mutation / Nucleic Acids / Substrate Specificity / DNA binding / Gene Targeting / Genome sequence / Nucleotides / Dimerization / DNA / Environmental Sciences / Humans / Mutation / Nucleic Acids / Substrate Specificity / DNA binding / Gene Targeting / Genome sequence / Nucleotides / Dimerization

Dendritic Targeting of mRNAs for Plasticity Genes in Experimental Models of Temporal Lobe Epilepsy

Animals / Male / Temporal Lobe Epilepsy / Neuronal Plasticity / Dendrites / Epilepsia / Clinical Sciences / Rats / Pilocarpine / Gene Targeting / Seizures / Protein isoforms / Subcellular Fractions / Reference Values / Neurosciences / Experimental Model / Epilepsia / Clinical Sciences / Rats / Pilocarpine / Gene Targeting / Seizures / Protein isoforms / Subcellular Fractions / Reference Values / Neurosciences / Experimental Model

Dendritic Targeting of mRNAs for Plasticity Genes in Experimental Models of Temporal Lobe Epilepsy

Animals / Male / Temporal Lobe Epilepsy / Neuronal Plasticity / Dendrites / Epilepsia / Clinical Sciences / Rats / Pilocarpine / Gene Targeting / Seizures / Protein isoforms / Subcellular Fractions / Reference Values / Neurosciences / Experimental Model / Epilepsia / Clinical Sciences / Rats / Pilocarpine / Gene Targeting / Seizures / Protein isoforms / Subcellular Fractions / Reference Values / Neurosciences / Experimental Model

Mammalian RNAi: a practical guide

Technology / Gene Silencing / Genetic Engineering / Biological Sciences / RNA interference / Humans / Animals / Gene Targeting / Transfection / Gene expression profiling / Humans / Animals / Gene Targeting / Transfection / Gene expression profiling

Mammalian RNAi: a practical guide

Technology / Gene Silencing / Genetic Engineering / Biological Sciences / RNA interference / Humans / Animals / Gene Targeting / Transfection / Gene expression profiling / Humans / Animals / Gene Targeting / Transfection / Gene expression profiling

Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice

Cognitive Science / Animal Behavior / Dopamine / Mice / Animals / Cocaine / Amphetamine / dopamine receptor D4 / Neurons / Neuron / Gene Targeting / G protein / Neurosciences / Motor activity / Cocaine / Amphetamine / dopamine receptor D4 / Neurons / Neuron / Gene Targeting / G protein / Neurosciences / Motor activity

Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener

Gene Therapy / DNA / Lung Cancer / Lipids / Cell line / Humans / Animals / Gene transfer techniques / Liposomes / Drug Delivery Systems / Gene Delivery / In Vivo / Neoplasms / Gene Targeting / Transfection / Quaternary Ammonium Compounds / Cations / Nude mice / Biochemistry and cell biology / Gene Transfer / Humans / Animals / Gene transfer techniques / Liposomes / Drug Delivery Systems / Gene Delivery / In Vivo / Neoplasms / Gene Targeting / Transfection / Quaternary Ammonium Compounds / Cations / Nude mice / Biochemistry and cell biology / Gene Transfer

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