Drug development - Page 2

Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Organic Chemistry / Drug development / Cell line / Tuberculosis / Humans / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry

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Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

Nonlinear dynamics / Drug Discovery / Pharmacokinetics / Drug development / Parameter estimation / Multivariate Analysis / Statistical Inference / First-Order Logic / Meta Analysis / Simulation Study / Reproducibility of Results / Statistical Estimation / Multivariate Analysis / Statistical Inference / First-Order Logic / Meta Analysis / Simulation Study / Reproducibility of Results / Statistical Estimation

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Hepatotoxicity, a global problem with local features: Toward the creation of a Pan-American Hepatotoxicity Network | Hepatotoxicidad, un problema global con especificidades locales: hacia la creación de una Red Hispano Latinoamericana de Hepatotoxicidad

Gastroenterology / Drug development / Spain / Latin America / Humans / Data Collection / Latin American / Registries / Clinical Sciences / Adverse Drug Reaction / Liver Disease / Drug Induced Liver Injury / Neurosciences / Data Collection / Latin American / Registries / Clinical Sciences / Adverse Drug Reaction / Liver Disease / Drug Induced Liver Injury / Neurosciences

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FR-190997, a nonpeptide bradykinin B2-receptor partial agonist, is a potent and efficacious intraocular pressure lowering agent in ocular hypertensive cynomolgus monkeys

Drug development / Humans / Animals / Benzophenones / Eye / Swine / Macaca fascicularis / Quinolines / Gene Expression Regulation / Ocular Hypertension / Swine / Macaca fascicularis / Quinolines / Gene Expression Regulation / Ocular Hypertension

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Leishmanicidal activity of polyphenolic-rich extract from husk fiber of Cocos nucifera Linn. (Palmae)

Microbiology / Medical Microbiology / Drug development / Leishmania / Flavonoids / Phytotherapy / Leishmaniasis / Polyphenols / Mice / Nitric oxide / Female / Animals / Cocos / Phenols / Plant extracts / Microbial Sensitivity Tests / Side Effect / Indexation / Rabbits / Antiviral Activity / Medicinal Plant / Phytotherapy / Leishmaniasis / Polyphenols / Mice / Nitric oxide / Female / Animals / Cocos / Phenols / Plant extracts / Microbial Sensitivity Tests / Side Effect / Indexation / Rabbits / Antiviral Activity / Medicinal Plant

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Myristoyl-CoA:Protein N-Myristoyltransferase, an Essential Enzyme and Potential Drug Target in Kinetoplastid Parasites

Kinetics / Drug development / Biological Chemistry / Leishmania / Cell Division / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting

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Myristoyl CoA: protein N-myristoyltransferase: an essential enzyme and potential drug target in kinetoplastid parasites

Kinetics / Drug development / Biological Chemistry / Leishmania / Cell Division / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting / Biological Sciences / Saccharomyces cerevisiae / Molecular / RNA interference / Virulence / Cell line / Humans / Mice / Endocytosis / Animals / Cell Death / Biological / Polymerase Chain Reaction / Capsid / Phenotype / Enzyme / CHEMICAL SCIENCES / Mouse Model / Rats / Trypanosoma / Trypanosoma brucei / Time Factors / Trypanosoma brucei brucei / Isoenzymes / Fatty Acid / Protozoan Proteins / Species Specificity / Amino Acid Sequence / Subcellular Fractions / Golgi Apparatus / Recombinant Proteins / Drug Targeting / Cell Survival / Leishmania Major / Biochemistry and cell biology / Poliovirus / Immunoblotting

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Rhizophora mangle L. (mangle rojo): Una especie con potencialidades de uso terapéutico [Rhizophora mangle L. (red mangrove): A species with potential therapeutic uses]

Mangroves / Wound Healing / Drug development / Antioxidants / Insecticides / Antioxidant / Insecticide / Anti-inflammatory activity / Antioxidant Activity / Anti-inflammatory / Anti Inflammatory Activity / Anti-Inflammatory Activities / Antioxidation / Therapeutic Properties of Medicinal Plant / Larvicides, / Rhizophora mangle / Antidiarrheal / Antioxidant / Insecticide / Anti-inflammatory activity / Antioxidant Activity / Anti-inflammatory / Anti Inflammatory Activity / Anti-Inflammatory Activities / Antioxidation / Therapeutic Properties of Medicinal Plant / Larvicides, / Rhizophora mangle / Antidiarrheal

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La bioinformática estructural o la realidad virtual de los medicamentos

Drug Discovery / Drug development / Structural Bioinformatics / Realidade Virtual / Enzyme / Rational drug design / Chronic Inflammation / In Silico / ACE Inhibitor / Rational drug design / Chronic Inflammation / In Silico / ACE Inhibitor

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Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models

Traumatic Brain Injury / Drug development / Brain / Humans / Child / Female / Animals / Male / Nicotinic Acetylcholine Receptors / Young Adult / Clinical Sciences / Rats / Swine / Autoradiography / Survival Time / Neurosciences / Experimental Model / Brain injuries / Random Allocation / Female / Animals / Male / Nicotinic Acetylcholine Receptors / Young Adult / Clinical Sciences / Rats / Swine / Autoradiography / Survival Time / Neurosciences / Experimental Model / Brain injuries / Random Allocation

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Statistical Model To Evaluate In Vivo Activities of Antimalarial Drugs in a Plasmodium cynomolgi-Macaque Model for Plasmodium vivax Malaria

Microbiology / Medical Microbiology / Drug development / Prodrugs / Mixed Effects Models / Female / Animals / Drug Resistance / Male / Animal Model / South America / Animal Experimentation / In Vivo / Antimalarials / Rhesus macaques / Antimicrobial agents / Macaca Mulatta / Sub Saharan Africa / Statistical Model / Mechanism of action / Host Range / Biological activity / Plasmodium Vivax / Treatment Effect / Female / Animals / Drug Resistance / Male / Animal Model / South America / Animal Experimentation / In Vivo / Antimalarials / Rhesus macaques / Antimicrobial agents / Macaca Mulatta / Sub Saharan Africa / Statistical Model / Mechanism of action / Host Range / Biological activity / Plasmodium Vivax / Treatment Effect

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Leishmanicidal Metabolites from Cochliobolus sp., an Endophytic Fungus Isolated from Piptadenia adiantoides (Fabaceae)

Drug development / Biological Sciences / Cell line / Humans / Central America / Female / Melanoma / Animals / Economic Impact / South America / Endophytic Fungi / Trypanosoma / Trypanosoma Cruzi / Fabaceae / World Health Organization / Tropical Climate / Ribosomal DNA / Recombinant Proteins / Ascomycota / Benzoquinones / Confidence Interval / Female / Melanoma / Animals / Economic Impact / South America / Endophytic Fungi / Trypanosoma / Trypanosoma Cruzi / Fabaceae / World Health Organization / Tropical Climate / Ribosomal DNA / Recombinant Proteins / Ascomycota / Benzoquinones / Confidence Interval

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Leishmanicidal activity of polyphenolic-rich extract from husk fiber of Cocos nucifera Linn. (Palmae)

Microbiology / Medical Microbiology / Drug development / Leishmania / Flavonoids / Phytotherapy / Leishmaniasis / Polyphenols / Mice / Nitric oxide / Female / Animals / Cocos / Phenols / Plant extracts / Phagocytosis / Microbial Sensitivity Tests / Side Effect / Indexation / Rabbits / Antiviral Activity / Medicinal Plant / Phytotherapy / Leishmaniasis / Polyphenols / Mice / Nitric oxide / Female / Animals / Cocos / Phenols / Plant extracts / Phagocytosis / Microbial Sensitivity Tests / Side Effect / Indexation / Rabbits / Antiviral Activity / Medicinal Plant

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Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Organic Chemistry / Drug development / Cell line / Tuberculosis / Humans / Mycobacterium tuberculosis / Developing Country / Infectious Disease / ABS / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry / Mycobacterium tuberculosis / Developing Country / Infectious Disease / ABS / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry

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