Drug Resistance

A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene

DNA damage / Biological Sciences / Environmental Sciences / Mutation / Mice / Animals / Drug Resistance / Comet Assay / Environmental / Animals / Drug Resistance / Comet Assay / Environmental

A Picomolar Inhibitor of Resistant Strains of Human Immunodeficiency Virus Protease Identified by a Combinatorial Approach

Kinetics / Mutation / HIV protease / Drug Resistance / Drug Design / Enzyme / Human immunodeficiency virus / Protease Inhibitors / Substrate Specificity / Amino Acid Profile / Amino Acid Substitution Rates / Biochemistry and cell biology / Enzyme / Human immunodeficiency virus / Protease Inhibitors / Substrate Specificity / Amino Acid Profile / Amino Acid Substitution Rates / Biochemistry and cell biology

Terapia biológica en oftalmía simpática refractaria a tratamiento inmunosupresor combinado

Humans / Female / Drug Resistance / Retinal detachment / Cyclosporine / Optometry and Ophthalmology / Adult / Methotrexate / Tumor necrosis factor-alpha / Combination drug therapy / Optometry and Ophthalmology / Adult / Methotrexate / Tumor necrosis factor-alpha / Combination drug therapy

Application of transcranial magnetic stimulation in treatment of drug-resistant major depression?a report of two cases

Psychology / Cognitive Science / Transcranial Magnetic Stimulation / Human / Drug Resistance / Major Depression

A vincristine-resistant murine erythroleukemia cell line secretes a differentiation enhancing factor

Kinetics / Cell line / Cell Differentiation / Mice / Animals / Drug Resistance / Culture Media / Leukemia Inhibitory Factor / Biochemistry and cell biology / Interleukin / Drug Resistance / Culture Media / Leukemia Inhibitory Factor / Biochemistry and cell biology / Interleukin

Doses intermitentes de estatina em pacientes em hemodiálise com LDL-colesterol espontaneamente baixo

Atherosclerosis / Erythropoietin / Malnutrition / Prospective studies / Humans / Female / Drug Resistance / Male / Young Adult / Anemia / Nutritional Status / Aged / Middle Aged / C reactive protein / Adult / Biological markers / Hemoglobins / Simvastatin / Renal Dialysis / Female / Drug Resistance / Male / Young Adult / Anemia / Nutritional Status / Aged / Middle Aged / C reactive protein / Adult / Biological markers / Hemoglobins / Simvastatin / Renal Dialysis

Adaptive Copy Number Evolution in Malaria Parasites

Genetics / Geography / Polymorphism / Molecular Evolution / Thailand / LAOS / Humans / Animals / Drug Resistance / Polymerase Chain Reaction / Parallel Evolution / Gene Dosage / Enzyme / Positive Selection / Plasmodium falciparum / Antimalarials / Linkage Disequilibrium / PLoS Genetics / LAOS / Humans / Animals / Drug Resistance / Polymerase Chain Reaction / Parallel Evolution / Gene Dosage / Enzyme / Positive Selection / Plasmodium falciparum / Antimalarials / Linkage Disequilibrium / PLoS Genetics

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition

Multidisciplinary / Nature / Humans / Mice / Animals / Drug Resistance / Acute Lymphoblastic Leukaemia / Tyrosine Kinase Inhibitor / Cell Survival / DNA binding proteins / Protein Kinase Inhibitors / Tyrosine Kinase / Drug Resistance / Acute Lymphoblastic Leukaemia / Tyrosine Kinase Inhibitor / Cell Survival / DNA binding proteins / Protein Kinase Inhibitors / Tyrosine Kinase

Anti-plasmodial activity of Ailanthus excelsa

Complementary and Alternative Medicine / Plant Biology / Animals / Drug Resistance / Detoxification / Ailanthus / Plant extracts / Plasmodium falciparum / Fitoterapia / Protozoan Proteins / Chloroquine / Erythrocytes / Ailanthus / Plant extracts / Plasmodium falciparum / Fitoterapia / Protozoan Proteins / Chloroquine / Erythrocytes

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

Microbiology / Immunology / Medical Microbiology / Humans / Animals / Drug Resistance / Plasmodium falciparum / Culicidae / Protozoan Proteins / Drug Resistance / Plasmodium falciparum / Culicidae / Protozoan Proteins

Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant

Genetics / Membrane Proteins / Gene expression / Multidisciplinary / Xenopus / Humans / Mutation / Female / Animals / Drug Resistance / Phenotype / Molecular cloning / Protozoan Proteins / Amino Acid Sequence / Oocytes / Humans / Mutation / Female / Animals / Drug Resistance / Phenotype / Molecular cloning / Protozoan Proteins / Amino Acid Sequence / Oocytes

Antimicrobial Drug Resistance

Veterinary Medicine / Virulence / Therapeutic drug monitoring / Mutation / Animals / Drug Resistance / Bacteria / Microbial genetic and drug resistance / Anti-Bacterial Agents / Time Factors / Bacterial infections / Drug Tolerance / Drug Resistance / Bacteria / Microbial genetic and drug resistance / Anti-Bacterial Agents / Time Factors / Bacterial infections / Drug Tolerance

Antiviral prophylaxis during pandemic influenza may increase drug resistance

Microbiology / Medical Microbiology / Enzyme Inhibitors / Disease Outbreaks / Uncertainty / Humans / Computer Simulation / Pandemic Influenza / Drug Resistance / Social distance / Neuraminidase / Clinical Sciences / Prevalence / Basic Reproduction Number / Antiviral Agents / Humans / Computer Simulation / Pandemic Influenza / Drug Resistance / Social distance / Neuraminidase / Clinical Sciences / Prevalence / Basic Reproduction Number / Antiviral Agents

Impaired fitness of drug-resistant malaria parasites: evidence and implication on drug-deployment policies

Malaria / Folic acid / Plasmodium / Humans / Mutation / Animals / Drug Resistance / Host-parasite interactions / Biological evolution / Clinical Sciences / Antimalarials / Animals / Drug Resistance / Host-parasite interactions / Biological evolution / Clinical Sciences / Antimalarials

Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports

British medical history / Case Report / Humans / Female / Drug Resistance / Male / Infant / Naphthoquinones / High Pressure Liquid Chromatography / Public health systems and services research / ATOVAQUONE / Plasmodium falciparum / Antimalarials / BMJ / Tablets / Combination drug therapy / Male / Infant / Naphthoquinones / High Pressure Liquid Chromatography / Public health systems and services research / ATOVAQUONE / Plasmodium falciparum / Antimalarials / BMJ / Tablets / Combination drug therapy

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

Kinetics / Multidisciplinary / Nature / Adenosine / Animals / Drug Resistance / Trypanosoma brucei brucei / Adenine / Arsenicals / Drug Resistance / Trypanosoma brucei brucei / Adenine / Arsenicals

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