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Drug Design
Drug Design
Neuropeptide Y as an Endogenous Antiepileptic, Neuroprotective and Pro-Neurogenic Peptide
Hippocampus / Humans / Animals / Drug Design / Temporal Lobe Epilepsy / Neurons / Neuropeptide Y / Glutamic Acid / Neuroprotective Agents / Neurons / Neuropeptide Y / Glutamic Acid / Neuroprotective Agents
Neuropeptide Y as an Endogenous Antiepileptic, Neuroprotective and Pro-Neurogenic Peptide
Hippocampus / Humans / Animals / Drug Design / Temporal Lobe Epilepsy / Neurons / Neuropeptide Y / Glutamic Acid / Neuroprotective Agents / Neurons / Neuropeptide Y / Glutamic Acid / Neuroprotective Agents
Local RNA Target Structure Influences siRNA Efficacy: A Systematic Global Analysis
Thermodynamics / Molecular Biology / Computational Biology / Gene Silencing / Global Analysis / Genetic Engineering / Molecular / RNA interference / Cercopithecus aethiops / Cell line / Humans / RNAi / Animals / Drug Design / Free Energy / Rats / dsRNA / Substrate Specificity / Fluorescent Protein / Transfection / siRNA / RNA Structure / Base Sequence / TRP / UTR / GFP / Nucleic Acid Conformation / Biochemistry and cell biology / Enterovirus / Genetic Engineering / Molecular / RNA interference / Cercopithecus aethiops / Cell line / Humans / RNAi / Animals / Drug Design / Free Energy / Rats / dsRNA / Substrate Specificity / Fluorescent Protein / Transfection / siRNA / RNA Structure / Base Sequence / TRP / UTR / GFP / Nucleic Acid Conformation / Biochemistry and cell biology / Enterovirus
Local RNA Target Structure Influences siRNA Efficacy: A Systematic Global Analysis
Thermodynamics / Molecular Biology / Computational Biology / Gene Silencing / Global Analysis / Genetic Engineering / Molecular / RNA interference / Cercopithecus aethiops / Cell line / Humans / RNAi / Animals / Drug Design / Free Energy / Rats / dsRNA / Substrate Specificity / Fluorescent Protein / Transfection / siRNA / RNA Structure / Base Sequence / TRP / UTR / GFP / Nucleic Acid Conformation / Biochemistry and cell biology / Enterovirus / Genetic Engineering / Molecular / RNA interference / Cercopithecus aethiops / Cell line / Humans / RNAi / Animals / Drug Design / Free Energy / Rats / dsRNA / Substrate Specificity / Fluorescent Protein / Transfection / siRNA / RNA Structure / Base Sequence / TRP / UTR / GFP / Nucleic Acid Conformation / Biochemistry and cell biology / Enterovirus
In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity
Organic Chemistry / Medicinal Chemistry / Obesity / Pharmacokinetics / Pharmaceutical Chemistry / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity
Ariel Fernandez Scientist/Consultant Website
Biophysics / Pharmaceuticals / Drug Design
Ariel Fernandez Scientist/Consultant Website
Biophysics / Drug Design
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification
Organic Chemistry / Pharmacokinetics / In Vitro / Humans / Animals / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides
Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process
Enzyme Inhibitors / Humans / Drug Design / Fragmentation / Enzyme / Active site / Time Dependent / Substrate Specificity / Serine Protease / Methyl Ester / Biochemistry and cell biology / Active site / Time Dependent / Substrate Specificity / Serine Protease / Methyl Ester / Biochemistry and cell biology
Multidimensional De Novo Design Reveals 5-HT2B Receptor-Selective Ligands
Microfluidics / Computer Aided Design / Humans / Amines / Drug Design / CHEMICAL SCIENCES / Protein Binding / Ligands / CHEMICAL SCIENCES / Protein Binding / Ligands
Quinone-amino acid conjugates targeting Leishmania amino acid transporters
Multidisciplinary / Cell line / Humans / Feasibility Studies / Drug Design / Naphthoquinones / PLoS one / Lysine / Arginine / Naphthoquinones / PLoS one / Lysine / Arginine
Isocitrate lyase: a potential target for anti-tubercular drugs
Tuberculosis / Humans / Mycobacterium tuberculosis / Mice / Animals / Drug Design / Molecular Targeted Therapy / Drug Design / Molecular Targeted Therapy
Complementary medicinal chemistry‐driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates
Immunology / Medical Microbiology / Treatment / Drug Discovery / Leishmania / Pharmaceutical Chemistry / Leishmaniasis / Humans / Animals / Lead / Drug Design / Complementary Medicine / Trypanosoma / Trypanosomiasis / Trypanocidal Agents / Quinazolines / Pharmaceutical Chemistry / Leishmaniasis / Humans / Animals / Lead / Drug Design / Complementary Medicine / Trypanosoma / Trypanosomiasis / Trypanocidal Agents / Quinazolines
CaMKII-regulated NMDA receptor expression
Drug development / Dopamine / Glutamate / Drug Design
Paclitaxel ameliorates renal fibrosis
Drug development / Drug Design / Paclitaxel / Tubulin
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties
Organic Chemistry / Kinetics / Pharmaceutical Chemistry / Humans / Drug Design / Peptides / Enzyme Inhibition / Gonadotropin Releasing Hormone / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ions / Molecular Structure / Peptides / Enzyme Inhibition / Gonadotropin Releasing Hormone / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ions / Molecular Structure
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