Blood brain barrier

Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Dogs / Humans / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure

Imaging of intraneural edema by using gadolinium-enhanced MR imaging: experimental compression injury

Electron Microscopy / Magnetic Resonance Imaging / Fluorescence Microscopy / Transmission Electron Microscopy / Dogs / Blood brain barrier / Animals / Carpal Tunnel Syndrome / Clinical Sciences / Edema / Peripheral Nerve / Mr Imaging / Neurosciences / Median Nerve / Tight Junction / Contrast Media / Blood brain barrier / Animals / Carpal Tunnel Syndrome / Clinical Sciences / Edema / Peripheral Nerve / Mr Imaging / Neurosciences / Median Nerve / Tight Junction / Contrast Media

Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

Neurochemistry / Dopamine / Mice / Blood brain barrier / Animals / Male / dopamine receptor D4 / Rats / Atypical Antipsychotics / Wistar Rats / Protein Binding / Neurosciences / Male / dopamine receptor D4 / Rats / Atypical Antipsychotics / Wistar Rats / Protein Binding / Neurosciences

A diet-induced mouse model for glutaric aciduria type I

Magnetic Resonance Imaging / Diet / Survival Analysis / Brain / Mice / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions

La melatonina: un coadyuvante potencial en el tratamiento de las demencias

Free Radical / Nitric oxide / Blood brain barrier / Acetylcholinesterase / Salud Mental / Glutathione Peroxidase / Salud / Actin Dynamics / Mental Disorder / Superoxide Dismutase / Clinical Sciences / Antioxidant enzyme / Neuronal Death / Calmodulin / Neurodegenerative Disease / Singlet Oxygen / Pineal Gland / Cellular Structure / Glutathione Reductase / Drug Targeting / Brain Damage / Paired Helical Filament / Senile Plaques / Glutathione Peroxidase / Salud / Actin Dynamics / Mental Disorder / Superoxide Dismutase / Clinical Sciences / Antioxidant enzyme / Neuronal Death / Calmodulin / Neurodegenerative Disease / Singlet Oxygen / Pineal Gland / Cellular Structure / Glutathione Reductase / Drug Targeting / Brain Damage / Paired Helical Filament / Senile Plaques

La melatonina: un coadyuvante potencial en el tratamiento de las demencias

Free Radical / Nitric oxide / Blood brain barrier / Acetylcholinesterase / Salud Mental / Glutathione Peroxidase / Salud / Actin Dynamics / Mental Disorder / Superoxide Dismutase / Clinical Sciences / Antioxidant enzyme / Neuronal Death / Calmodulin / Neurodegenerative Disease / Singlet Oxygen / Pineal Gland / Cellular Structure / Glutathione Reductase / Drug Targeting / Brain Damage / Paired Helical Filament / Senile Plaques / Glutathione Peroxidase / Salud / Actin Dynamics / Mental Disorder / Superoxide Dismutase / Clinical Sciences / Antioxidant enzyme / Neuronal Death / Calmodulin / Neurodegenerative Disease / Singlet Oxygen / Pineal Gland / Cellular Structure / Glutathione Reductase / Drug Targeting / Brain Damage / Paired Helical Filament / Senile Plaques

A diet-induced mouse model for glutaric aciduria type I

Magnetic Resonance Imaging / Diet / Survival Analysis / Brain / Mice / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions

A compartmental model for oxygen transport in brain microcirculation

Engineering / Mathematics / Microcirculation / Sensitivity Analysis / Brain / Computer Simulation / Carbon Monoxide / Diffusion / Sheep / Blood brain barrier / Animals / Metabolic rate / Oxygen Transport / Oxygen / Blood Viscosity / Blood Flow / Blood Flow Velocity / Blood Vessel / Computer Simulation / Carbon Monoxide / Diffusion / Sheep / Blood brain barrier / Animals / Metabolic rate / Oxygen Transport / Oxygen / Blood Viscosity / Blood Flow / Blood Flow Velocity / Blood Vessel

Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus

Kinetics / Multidisciplinary / Brain / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Blood brain barrier / Animals / Male / Drinking Water / Amino Acids / Glucose Transport / Rats / Body Weight / Amino Acid Profile / Streptozotocin / Diabetic Rat / Insulin / Diabetes mellitus / Blood brain barrier / Animals / Male / Drinking Water / Amino Acids / Glucose Transport / Rats / Body Weight / Amino Acid Profile / Streptozotocin / Diabetic Rat

Regional striatal DOPA transport and decarboxylase activity in Parkinson’s disease. J Nucl Med

Nuclear medicine / Humans / Caudate Nucleus / Blood brain barrier / Clinical Sciences / Middle Aged / Single Photon Emission Computed Tomography / Putamen / Parkinson Disease / Middle Aged / Single Photon Emission Computed Tomography / Putamen / Parkinson Disease

Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role

Multiple sclerosis / Cytokines / Humans / Blood brain barrier / Animals / Biochemical / Inflammatory disease / BIOCHEMICAL PHARMACOLOGY / Side Effect / Chemokines / Experimental Autoimmune Encephalomyelitis / Medicinal Plant / Oleanolic acid / Experimental Model / Biochemical / Inflammatory disease / BIOCHEMICAL PHARMACOLOGY / Side Effect / Chemokines / Experimental Autoimmune Encephalomyelitis / Medicinal Plant / Oleanolic acid / Experimental Model

Cortical Cholinergic Denervation Elicits Vascular Abeta Deposition

Microcirculation / Multidisciplinary / Cerebral Cortex / Blood brain barrier / Animals / Monoclonal Antibodies / Acetylcholine / Denervation / Rabbits / Alzheimer Disease / PLANT PROTEINS / immunoglobulin G / Immunotoxins / Functional Laterality / Monoclonal Antibodies / Acetylcholine / Denervation / Rabbits / Alzheimer Disease / PLANT PROTEINS / immunoglobulin G / Immunotoxins / Functional Laterality

Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria

Immune response / Inflammation / Survival Analysis / Multidisciplinary / Brain / Endothelial Cells / Mice / Nitric oxide / Blood brain barrier / Animals / Male / Systemic inflammation / PLoS one / Time Factors / Blood Vessels / Cerebral Malaria / Plasmodium berghei / Gene Expression Regulation / Inhaled Nitric Oxide / Endothelial Cells / Mice / Nitric oxide / Blood brain barrier / Animals / Male / Systemic inflammation / PLoS one / Time Factors / Blood Vessels / Cerebral Malaria / Plasmodium berghei / Gene Expression Regulation / Inhaled Nitric Oxide

Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria

Immune response / Inflammation / Survival Analysis / Multidisciplinary / Brain / Endothelial Cells / Mice / Nitric oxide / Blood brain barrier / Animals / Male / Systemic inflammation / PLoS one / Time Factors / Blood Vessels / Cerebral Malaria / Plasmodium berghei / Gene Expression Regulation / Inhaled Nitric Oxide / Endothelial Cells / Mice / Nitric oxide / Blood brain barrier / Animals / Male / Systemic inflammation / PLoS one / Time Factors / Blood Vessels / Cerebral Malaria / Plasmodium berghei / Gene Expression Regulation / Inhaled Nitric Oxide

A diet-induced mouse model for glutaric aciduria type I

Magnetic Resonance Imaging / Diet / Survival Analysis / Brain / Mice / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions / Blood brain barrier / Female / Animals / Plant tissue Culture Techniques / Male / Astrocyte / Animal Model / Neurons / Mouse Model / Lysine / Subarachnoid haemorrhage / Human Disease / Dietary Protein / High-protein Diet / Autosomal Recessive / White Matter Lesions
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