Antimalarials

Aryl aryl methyl thio arenes prevent multidrug-resistant malaria in mouse by promoting oxidative stress in parasites

Malaria / Oxidative Stress / Mice / EC / Animals / Drug Resistance / Male / Glutathione / Heme / Polycyclic aromatic hydrocarbons (PAHs) / Plasmodium falciparum / Antimalarials / Ec / Biochemistry and cell biology / Drug Resistance / Male / Glutathione / Heme / Polycyclic aromatic hydrocarbons (PAHs) / Plasmodium falciparum / Antimalarials / Ec / Biochemistry and cell biology

Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon

Microbiology / Medical Microbiology / Treatment Outcome / Adolescent / Humans / Child / Gabon / Female / Animals / Drug Resistance / Male / Recurrence / Sesquiterpenes / Combination chemotherapy / Adverse Event / Plasmodium falciparum / Antimalarials / Antimicrobial agents / World Health Organization / Body Weight / Sub Saharan Africa / Drug treatment / Child / Gabon / Female / Animals / Drug Resistance / Male / Recurrence / Sesquiterpenes / Combination chemotherapy / Adverse Event / Plasmodium falciparum / Antimalarials / Antimicrobial agents / World Health Organization / Body Weight / Sub Saharan Africa / Drug treatment

Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum isolates from Gabon

Microbiology / Medical Microbiology / Humans / Gabon / Animals / Plasmodium falciparum / Antimalarials / Biological activity / Plasmodium falciparum / Antimalarials / Biological activity

Glutathione‐S‐transferase activity in malarial parasites

Tropical Medicine / Tropical medicine (Health Sciences) / Humans / Mice / Animals / Drug Resistance / Glutathione / Heme / Public health systems and services research / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Glutathione Transferase / Plasmodium yoelii / Chloroquine / Plasmodium Knowlesi / Plasmodium berghei / Drug Resistance / Glutathione / Heme / Public health systems and services research / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Glutathione Transferase / Plasmodium yoelii / Chloroquine / Plasmodium Knowlesi / Plasmodium berghei

Antiplasmodial alkaloids from Desmos rostrata

Natural Products / Medicinal Plants / Vietnam / Biological Sciences / Humans / Animals / Alkaloids / CHEMICAL SCIENCES / Plasmodium falciparum / Antimalarials / Natural / KB cells / Molecular Structure / Animals / Alkaloids / CHEMICAL SCIENCES / Plasmodium falciparum / Antimalarials / Natural / KB cells / Molecular Structure

Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea

Magnetic Resonance Spectroscopy / Animals / Drug Resistance / Terpenes / Sesquiterpenes / Plant extracts / Plasmodium falciparum / Antimalarials / Sensitivity and Specificity / Chloroquine / Structure activity Relationship / Lactones / Molecular Structure / Plant extracts / Plasmodium falciparum / Antimalarials / Sensitivity and Specificity / Chloroquine / Structure activity Relationship / Lactones / Molecular Structure

Short-Course Artesunate Treatment of Uncomplicated Plasmodium falciparum Malaria in Gabon

Microbiology / Medical Microbiology / Treatment Outcome / Adolescent / Humans / Child / Gabon / Female / Animals / Drug Resistance / Male / Recurrence / Sesquiterpenes / Combination chemotherapy / Adverse Event / Plasmodium falciparum / Antimalarials / Antimicrobial agents / World Health Organization / Body Weight / Sub Saharan Africa / Drug treatment / Child / Gabon / Female / Animals / Drug Resistance / Male / Recurrence / Sesquiterpenes / Combination chemotherapy / Adverse Event / Plasmodium falciparum / Antimalarials / Antimicrobial agents / World Health Organization / Body Weight / Sub Saharan Africa / Drug treatment

Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda

Uganda / Health Policy / Humans / Child / Infant / Pyrimethamine / Sulfadoxine / Adverse Event / Antimalarials / Combination drug therapy / Chloroquine / Life Span / Amodiaquine / The American / Pyrimethamine / Sulfadoxine / Adverse Event / Antimalarials / Combination drug therapy / Chloroquine / Life Span / Amodiaquine / The American

In Vitro Sensitivities of Plasmodium falciparum to Different Antimalarial Drugs in Uganda

Microbiology / Medical Microbiology / Uganda / Treatment Outcome / Humans / Child / Mutation / Drug Resistance / Membrane transport proteins / Plasmodium falciparum / Antimalarials / Antimicrobial agents / Protozoan Proteins / Quinolines / Chloroquine / Cohort Studies / Child / Mutation / Drug Resistance / Membrane transport proteins / Plasmodium falciparum / Antimalarials / Antimicrobial agents / Protozoan Proteins / Quinolines / Chloroquine / Cohort Studies

CYP2C8 polymorphism frequencies among malaria patients in Zanzibar

Polymorphism / Tanzania / Humans / Pharmacogenetics / Female / Male / Infant / European / Prevalence / Antimalarials / Amodiaquine / Male / Infant / European / Prevalence / Antimalarials / Amodiaquine

Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines)

Pharmacy / Malaria / In Vitro / Toxicity / Mice / Pharmacology and Clinical pharmacy / Female / Animals / Antimalarials / Alkylation / Acylation / Biological activity / Chloroquine / Chemical Synthesis / Plasmodium berghei / Pharmacology and Clinical pharmacy / Female / Animals / Antimalarials / Alkylation / Acylation / Biological activity / Chloroquine / Chemical Synthesis / Plasmodium berghei

Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata

Complementary and Alternative Medicine / Plant Biology / Pharmacognosy / Drug Resistance / Quinones / Rubiaceae / Plant Roots / Anthraquinones / Plant extracts / Plasmodium falciparum / Antimalarials / Rubiaceae / Plant Roots / Anthraquinones / Plant extracts / Plasmodium falciparum / Antimalarials

Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity

Malaria / Mice / Animals / Rubiaceae / Plant Roots / Plant extracts / Antimalarials / Chloroquine / Plasmodium berghei / Plant extracts / Antimalarials / Chloroquine / Plasmodium berghei

The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria

Nonparametric Statistics / British / Pharmacokinetics / Humans / Female / Male / Confidence intervals / Sesquiterpenes / Adult / Antimalarials / Cross-Over Studies / Area Under Curve / Male / Confidence intervals / Sesquiterpenes / Adult / Antimalarials / Cross-Over Studies / Area Under Curve

Antimalarial Exposure Delays Plasmodium falciparum Intra-Erythrocytic Cycle and Drives Drug Transporter Genes Expression

Cell Cycle / Gene expression / Multidisciplinary / Drug Resistance / Membrane transport proteins / PLoS one / Plasmodium falciparum / Antimalarials / Combination drug therapy / Protozoan Proteins / Erythrocytes / Non linear regression / Mefloquine / Gene Expression Regulation / PLoS one / Plasmodium falciparum / Antimalarials / Combination drug therapy / Protozoan Proteins / Erythrocytes / Non linear regression / Mefloquine / Gene Expression Regulation

In vitro and in vivo inhibition of erythrocytic development of malarial parasites by docetaxel

Microbiology / Medical Microbiology / Malaria / Plasmodium / Cell Division / Mice / Female / Animals / Drug Resistance / Male / Paclitaxel / Life Cycle / Plasmodium falciparum / Antimalarials / Biological Process / Microbial Sensitivity Tests / Erythrocytes / Mice / Female / Animals / Drug Resistance / Male / Paclitaxel / Life Cycle / Plasmodium falciparum / Antimalarials / Biological Process / Microbial Sensitivity Tests / Erythrocytes

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